基于PET/CT图像的动物尾静脉渗漏校正方法  

Simulation method based on PET image for tail vein extravasation correction

作　　者：闫宇昊 杨治平 全志永 高玉花 康飞 汪静 Yan Yuhao;Yang Zhiping;Quan Zhiyong;Gao Yuhua;Kang Fei;Wang Jing(Department of Nuclear Medicine,the First Affiliated Hospital of the Air Force Military Medical University,Xi′an 710032,China)

机构地区：[1]空军军医大学第一附属医院核医学科,西安710032

出　　处：《中华核医学与分子影像杂志》2023年第5期295-298,共4页Chinese Journal of Nuclear Medicine and Molecular Imaging

基　　金：国家自然科学基金(91959208, 81871379)。

摘　　要：目的建立一种将PET图像活度转换为实际活度的尾静脉渗漏校正方法, 以提高SUV计算的准确性。方法使用Nano PET/CT进行模体显像, 采用有序子集最大期望值迭代法对图像进行三维重建, 使用仪器自带软件分析PET图像, 确定最佳扫描时间和ROI自动勾画阈值。通过对比模拟公式计算的模拟活度和直接用活度计测量鼠尾的标准活度, 在雄性昆明小鼠(n=11)上验证模拟方法的准确性, 并探究尾静脉渗漏对SUV的影响。采用两独立样本t检验分析数据。结果最佳扫描时间为10 min, 以SUVmax 42%为阈值进行ROI自动勾画。校正公式为:当0.3 MBq/ml≤渗漏浓度<6.5 MBq/ml时, 实际活度(MBq)=图像活度(MBq)/(4.48×V+77.05)×100;当6.5 MBq/ml≤渗漏浓度<14.8 MBq/ml时, 实际活度(MBq)=图像活度(MBq)/(6.65×V+71.10)×100。模拟方法与活度计测量的差异率为(6.10±2.43)%。在实际操作验证中, SUV被低估了(6.07±2.67)%, 校正后SUV(0.276±0.078)与标准SUV(0.277±0.078)差异无统计学意义(t=0.99, P=0.353), 而未校正的SUV(0.264±0.078)显著低于标准SUV(t=7.02, P<0.001)。结论基于PET图像的校正计算方法可实现尾静脉渗漏活度和动物显像SUV结果的准确校正。Objective To establish a method for correction of tail vein extravasation based on PET images and to improve the accuracy of SUV.Methods The simulation method was established by phantom on Nano PET/CT and images were reconstructed by a three-dimensional ordered-subsets exception maximum algorithm.PET images were analyzed by using the Interview Fusion 1.0 software.The optimal scanning time and the ROI delineated method were found.The accuracy of the simulation method was verified by comparing the activity of simulation method with the mice tail activity measured by the dose calibrator directly on Kunming(KM)mouse(n=11).Using the simulation method,the impact of extravasation on SUV was proved.Independent-sample t test was used to analyze data.Results Ten minutes was selected as the optimal scanning time and SUVmax 42%threshold was selected as the ROI delineated method.The specific correction formula was as follows:actual activity=image activity/(4.48×V+77.05)×100(0.3 MBq/ml≤leakage concentration<6.5 MBq/ml);actual activity=image activity/(6.65×V+71.10)×100(6.5 MBq/ml<leakage concentration≤14.8 MBq/ml).In the verification experiment,the difference rate between simulated and standard activity was(6.10±2.43)%.In actual operation verification,SUV was underestimated by(6.07±2.67)%.The corrected SUV(0.276±0.078)was not significantly different from the standard SUV(0.277±0.078;t=0.99,P=0.353),while the uncorrected SUV(0.264±0.078)was significantly lower than the standard SUV(t=7.02,P<0.001).Conclusion The correction calculation method based on PET images can realize the accurate correction of tail vein leakage activity and the SUV results of animal imaging.

关 键 词：诊断和治疗物质外渗 正电子发射断层显像术 体层摄影术 X线计算机 小鼠 

分 类 号：R543.6[医药卫生—心血管疾病] R817.4[医药卫生—内科学]