包虫病特异性疫苗抗原研究现状及展望  被引量:2

Research status and prospect of echinococcosis-specific vaccine antigens

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作  者:杨先伟 陶浪 魏金文 刘谨贤 YANG Xianwei;TAO Lang;WEI Jinwen;LIU Jinxian(Department of Thyroid Surgery,Sichuan Provincial People's Hospital,University of Electronic Science and Technology of China,Chengdu,610041,P.R.China;School of Medicine,University of Electronic Science and Technology of China,Chengdu 610056,P.R.China)

机构地区:[1]电子科技大学附属医院·四川省人民医院,四川省医学科学院·四川省人民医院,甲状腺外科,成都610072 [2]电子科技大学医学院,成都610056

出  处:《中国普外基础与临床杂志》2023年第6期734-738,共5页Chinese Journal of Bases and Clinics In General Surgery

基  金:国家自然科学基金(项目编号:82202548);四川省自然科学基金(项目编号:2022NSFSC0665)。

摘  要:目的总结包虫病特异性疫苗抗原研究现状,分析其来源及应用前景,以期为包虫病疫苗抗原研发和药物治疗提供新思路。方法检索国内外有关包虫病特异性疫苗抗原相关的研究并进行综述。结果天然包虫抗原,如囊液粗抗原、原头节、生发层等,由于材料获取困难和制备繁琐,常常会出现批间差异而造成敏感度、特异度等评价指标不稳定。新型重组包虫自身特异抗原、多肽、DNA分子等结构已知,重复性和特异性较好,更适合批量化生产测试,是目前研究的主要方向,如rAgB8/1、rEm18、rEm2等。结论疫苗研发是攻克包虫病的主要方向之一,在棘球蚴与人或动物宿主的相互作用中,棘球蚴自身结构蛋白及排泄/分泌蛋白等刺激宿主产生抗虫免疫和免疫清除,寻找这些特异性蛋白抗原对于疫苗研发及新型药物治疗具有重要意义。Objective To summarize the research status of echinococcosis-specific vaccine antigens,analyze their sources and application prospects,and to provide new ideas for the development of echinococcosis vaccine antigens and drug treatment.Method Research on echinococcosis-specific vaccine antigens at home and abroad was searched and reviewed.Results Natural hydatid antigens,such as cystic fluid crude antigen,protoscolex segment,germinal layer,etc.often appear due to the difficulty of material acquisition and cumbersome preparation,resulting in unstable evaluation indicators such as sensitivity and specificity.The gene or protein sequences of a new recombinant hydatid antigen was accessible,the reproducibility and specificity were better,and it was more suitable for batch production testing,which was the main direction of current research,such as rAgB8/1,rEm18,rEm2,etc.Conclusions Vaccine development is one of the main directions for the elimination of hydatidosis.In the interaction between echinococcus and human or animal hosts,the natural structural proteins or excretion/secretion proteins of echinococcus stimulate the host to produce antiparasites immunity and immune clearance,and the search for these specific protein antigens is of great significance for vaccine development,and new drug treatment.

关 键 词:包虫病 疫苗 Eg95蛋白 基因重组 抗原 

分 类 号:R392-33[医药卫生—免疫学]

 

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