邹承鲁先生两项被收入教科书的研究成果  

Commemoration of Dr.Chen-Lu Tsou’s One Hundred Years of Birth

作　　者：王志新[1] WANG Zhi-Xin(School of Life Sciences,Tsinghua University,Beijing 100084,China)

机构地区：[1]清华大学生命科学学院,北京100084

出　　处：《生物化学与生物物理进展》2023年第5期861-866,共6页Progress In Biochemistry and Biophysics

摘　　要：邹承鲁先生出生于1923年5月17日,1951年于英国剑桥大学获博士学位。他长期从事蛋白质结构与功能的研究,作为近代中国生物化学的奠基人之一,在酶学研究领域做出了具有重要意义的工作。为了纪念邹承鲁先生诞辰100周年,特将邹先生60年前完成的两项重要的研究成果(蛋白质必需基团修饰程度和活性丧失的定量关系,酶活性不可逆抑制动力学)较详细地介绍给读者。希望通过本文的介绍,使读者看到老一辈科学家“是如何在资源匮乏的条件下,运用自己的聪明才智取得成就”的范例。Dr.Chen-Lu Tsou(1923-2006)obtained his doctorate from Cambridge in 1951,and became one of the founders of Chinese biochemistry.He spent most of his life on protein structure and function,making a number of original contributions.To commemorate his one hundred years of birth,two of his research achievements are elaborated in detail here,one of which is relation between the functional groups of proteins and their biological activity,and the other is on kinetics of irreversible modification of enzyme activity.This commemorative article intends to share with audiences how much can be achieved by the older generations of Chinese scientists with great minds but few resources,as epitomized in the two great pieces of work by Dr.TSOU.

关 键 词：酶 活性部位 动力学 化学修饰 酶抑制作用 

分 类 号：Q51[生物学—生物化学] Q55