具有分子伴侣功能的抗体  

Antibodies With Chaperone Function

作　　者：林景也 李森[1,2] LIN Jing-Ye;LI Sen(College of Life Sciences,Beijing Normal University,Beijing 100875,China;National Demonstration Center for Experimental Life Sciences&Biotechnology Education,Beijing Normal University,Beijing 100875,China)

机构地区：[1]北京师范大学生命科学学院,北京100875 [2]北京师范大学,生命科学与技术国家级实验教学示范中心,北京100875

出　　处：《生物化学与生物物理进展》2023年第5期1030-1041,共12页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金(30800188,31570756,32071222);北京市教育委员会共建项目资助。

摘　　要：蛋白质的折叠问题一直是生物学研究的前沿之一,蛋白质稳态平衡的破坏与衰老及很多神经退行性疾病的发病机理密切相关,而蛋白质的正确折叠与蛋白质稳态在很大程度上取决于分子伴侣参与构建的复杂网络。许多研究表明,抗体可以作为分子伴侣促进蛋白质的正确折叠,并阻止蛋白质的异常聚集,抗体所具有的严格底物特异性使其具备了治疗特定蛋白质折叠病、帮助包涵体复性等应用潜力。本文简要介绍了分子伴侣的研究进展,详细阐述了具有分子伴侣功能的抗体及单链抗体的研究进展,最后重点讨论了可抑制蛋白质聚集的抗体的研究近况。The problem of protein folding has been one of the frontiers of biological research.Disruption of proteostasis is closely related to ageing and the pathogenesis of many neurodegenerative diseases.The correct folding of proteins and proteostasis largely depend on the complex network including molecular chaperones.Many studies have shown that antibodies can act as molecular chaperones to promote proper protein folding and prevent abnormal protein aggregation.The strict substrate specificity gives them the potential to be used to treat specific protein-misfolding diseases and to help refolding of inclusion bodies.This paper briefly introduces the progress of research on molecular chaperones,elaborates the research progress of antibodies and single-chain fragment variable antibodies with chaperone function,and discusses on the recent research status of antibodies which can inhibit protein aggregation.

关 键 词：蛋白质折叠 分子伴侣 抗体 神经退行性疾病 

分 类 号：Q511[生物学—生物化学] Q71