链脲霉素诱导2型糖尿病雄性大鼠核糖与核糖激酶的变化  

Changes in Ribose and Ribokinase in STZ-induced Type 2 Diabetic Rat

作　　者：康念欣 于乐祥 刘缨 赫荣乔 KANG Nian-Xin;YU Le-Xiang;LIU Ying;HE Rong-Qiao(School of Life Sciences,Beijing University of Chinese Medicine,Beijing 102401,China;Institute of Biophysics,University of Chinese Academy of Sciences,Beijing 100101,China)

机构地区：[1]School of Life Sciences,Beijing University of Chinese Medicine,Beijing 102401,China [2]Institute of Biophysics,University of Chinese Academy of Sciences,Beijing 100101,China

出　　处：《生物化学与生物物理进展》2023年第5期1235-1238,共4页Progress In Biochemistry and Biophysics

基　　金：supported by grants from Beijing Brain Project(Z161100000217141);the Fundamental Research Funds for the Central Universities(2020-JYB-ZDGG-051)。

摘　　要：Dear Editor,Type 2 diabetes mellitus(T2DM)is a metabolic disorder that impacts multiple organs including brain activity through mechanisms such as glucose toxicity,insulin resistance,mitochondrial dysfunction,and vascular damage^([1-2]).As described by Su and his colleagues^([3])in 2013,type 2 diabetics had abnormally high levels of urine ribose,suggesting that the patients suffered from not only glucose metabolism disorders,but also ribose metabolism disorders^([4]).

关 键 词：链脲霉素 ORGANS URINE damage 

分 类 号：R587.1[医药卫生—内分泌]