Interactive mechanisms between caveolin-1 and actin filaments or vimentin intermediate filaments instruct cell mechanosensing and migration  

作　　者：Daijiao Tang Yue Zhang Jie Mei Jing Zhao Chenglin Miao Yaming Jiu 

机构地区：[1]Unit of Cell Biology and Imaging Study of Pathogen Host Interaction,The Center for Microbes,Development and Health,CAS Key Laboratory of Molecular Virology and Immunology,Institut Pasteur of Shanghai,Chinese Academy of Sciences,Shanghai 200031,China [2]University of Chinese Academy of Sciences,Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Journal of Molecular Cell Biology》2022年第11期1-8,共8页分子细胞生物学报（英文版）

基　　金：supported by the National Key Research and Development Program of China(2022YFC2303502 and 2021YFC2300204);the National Natural Science Foundation of China(32222022,92054104,and 31970660);CAS-VPST Silk Road Science Fund(GJHZ2021138);Shanghai Municipal Science and Technology Major Project(2019SHZDZX02).

摘　　要：Introduction Cell mechanosensing is the process that cell senses extracellular mechanical cues through mechanosensors and transduces them to downstream signaling pathways to alter cell mechanics and behaviors,which is involved in embryonic development(Gaetani et al.,2020),tissue regeneration(Fu et al.,2019),inflammatory response(Worbs et al.,2017),and tumor invasion and metastasis(Gargalionis et al.,2018).This ability is crucial for cells to adapt to mechanical stimuli(compressive force,shear stress,substrate rigidity,topology,adhesiveness,etc.)and maintain homeostasis(Chen et al.,2017).

关 键 词：MEC INVASION 

分 类 号：TP212[自动化与计算机技术—检测技术与自动化装置]