硝化应激与心血管疾病的研究进展  

Research progress on nitrative stress and cardiovascular diseases

作　　者：龚莉 邓玉婷 黄春华 陈雪品 戴红艳[2] GONG Li;DENG Yuting;HUANG Chunhua;CHEN Xuepin;DAI Hongyan(School of Clinical Medicine,Weifang Medical University,Weifang 261000,China;Heart Center of Qingdao Municipal Hospital,Qingdao 266000,China)

机构地区：[1]潍坊医学院临床医学院,潍坊261000 [2]青岛市市立医院心脏中心,青岛266000

出　　处：《生命的化学》2023年第4期479-485,共7页Chemistry of Life

基　　金：青岛市市南区科技计划项目(2022-2-011-YY);青岛市医疗卫生优秀学科带头人计划项目(青卫科教字[2019]9号)。

摘　　要：硝化应激可引起蛋白质发生硝基化修饰,对细胞产生毒性作用,导致细胞损伤及凋亡。另外,硝化应激在线粒体损伤以及炎症因子产生等病理生理过程中发挥重要作用。硝化应激在动脉粥样硬化、心肌缺血再灌注损伤、高血压、心力衰竭及糖尿病心肌病等心血管疾病的发生发展中起着关键作用。本文介绍了硝化应激的生物特性及其引起细胞损伤的作用机制,进而分析硝化应激在多种心血管疾病发生发展中的作用,以期为心血管疾病的防治提供新的思路和方法。Nitrative stress contributes to protein nitrification leading to cytotoxicity,cell damage and apoptosis.In addition,it plays the most crucial role in the pathophysiological processes,including mitochondrial damage and production of inflammatory factors.Recently,mounting evidence supports that nitrative stress plays vital part in the occurrence and development of cardiovascular diseases,such as atherosclerosis,myocardial ischemia/reperfusion injury,hypertension,heart failure and diabetic cardiomyopathy.This paper introduces the biological properties of nitrative stress and mechanism of nitrative stress on cell damage,and analyzes the role of nitrative stress in the occurrence and development of a variety of cardiovascular diseases,with the aim of providing new ideas and methods for the prevention and treatment of cardiovascular diseases.

关 键 词：硝化应激 过氧亚硝基阴离子 3-硝基酪氨酸 心血管疾病 

分 类 号：R54[医药卫生—心血管疾病]