中老年人中国内脏肥胖指数与新发高血压剂量-反应关系  

Dose-response relationship between visceral obesity index and new hypertension in middle-aged and elderly people

作　　者：钱涛铭 刘莉[2] 韩宇博[2] 盛小萌 邹国良[2] QIAN Tao-ming;LIU Li;HAN Yu-bo;SHENG Xiao-meng;ZOU Guo-liang(Heilongjiang University of Traditional Chinese Medicine,Harbin,Heilongjiang 150040,China;不详)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第一医院心血管一科,黑龙江哈尔滨150040

出　　处：《现代预防医学》2023年第11期1927-1931,共5页Modern Preventive Medicine

基　　金：国家自然科学基金(82074346);黑龙江省博士后资助项目(LBH-Z18253)。

摘　　要：目的采用多因素logistic回归模型探讨中老年人中国内脏肥胖指数(CVAI)与新发高血压之间的关系。方法数据来源于2011和2015年的中国健康与养老追踪调查(CHARLS)的数据。采用logistic回归探究中国内脏肥胖指数与新发高血压之间的关联,并通过建立三个模型来矫正七个因素(性别、受教育程度、居住地点、婚姻状况、吸烟状况、饮酒状况和睡眠时间)对结果的造成的潜在可能影响,同时采用限制立方样条模型来检查可能的非线性关联,将CVAI与高血压患病的剂量-反应关系可视化。结果研究共纳入4605名研究对象,其中新发高血压821人,CVAI最高组(Q4)的人群新患高血压的比例是CVAI指数最低组(Q1)的2.31倍(OR=2.31,95%CI:1.84~2.91)。使用限制性三次样条回归分析显示CVAI指数与新发高血压患病率之间存在剂量反应关系(P<0.001)且为非线性关系(Pnon-linear<0.001)。将CVAI指数作为连续性变量进行计算,在调整潜在混杂因素后,CVAI指数每上升一个四分位数,新发生高血压的患病比例增加51%。结论CVAI指数与新发高血压患病率密切相关且二者存在剂量-反应关系。Objective To explore the relationship between Chinese visceral adiposity index(CVAI)and new-onset hypertension in middle-aged and elderly people by using multivariate logistic regression model.Methods The data were collected from the China Health and Retirement Longitudinal Study(CHARLS)in 2011 and 2015.Logistic regression was used to explore the association between CVAI and new hypertension in China,and three models were established to correct for the potential effects of seven factors including gender,education,residence,marital status,smoking,drinking,and sleep time on the outcome.The restricted cubic spline model was used to examine the possible nonlinear association,and the dose-response relationship between CVAI and hypertension was visualized.Results A total of 4605 subjects were enrolled in the study,including 821 new-onset hypertensions.The proportion of new-onset hypertension in the group with the highest CVAI(Q4)was 2.31 times higher than that in the group with the lowest CVAI index(Q1)(OR=2.31,95%CI:1.84-2.91).Restricted cubic spline regression analysis showed that there was a dose-response relationship between CVAI index and the prevalence rate of new-onset hypertension(P<0.001)and a non-linear relationship(Pnon-linear<0.001).Taking the CVAI index as a continuous variable,after adjusting for potential confounding factors,for every quartile increase in the CVAI index,the proportion of new-onset hypertension increased by 51%.Conclusion CVAI index is closely related to the prevalence of new-onset hypertension and there is a dose-response relationship between them.

关 键 词：中老年人 中国内脏肥胖指数 新发高血压 剂量-反应关系 CHARLS 

分 类 号：R544.1[医药卫生—心血管疾病]