rs11362基因多态性和HIV-1发病风险关联性研究的Meta分析  

Meta-analysis of the association between gene polymorphism rs11362 and HIV-1 risk

作　　者：李昕[1] 郝政 韦丽[3] 时红杰 徐园园[1] 吴苏姝[1] 沈小勇 朱正平[1] LI Xin;HAO Zheng;WEI Li;SHI Hong-jie;XU Yuan-yuan;WU Su-shu;SHEN Xiao-yong;ZHU Zheng-ping(Department of AIDS and STD Control,Nanjing Center for Disease Control and Prevention,Nanjing,Jiangsu 210003,China;不详)

机构地区：[1]南京市疾病预防控制中心艾滋病与性病防制科,江苏南京210003 [2]南京市鼓楼区中央门社区卫生服务中心小儿先髋科 [3]南京市疾病预防控制中心环境卫生科 [4]南京市江宁区土桥社区医院预防保健科

出　　处：《现代预防医学》2023年第11期2094-2100,共7页Modern Preventive Medicine

基　　金：南京市重点医学专科项目(传染病控制专项);南京市卫生科技发展项目(医学重点项目)(ZKX19050,ZKX20046)。

摘　　要：目的目前有很多关于rs11362基因多态性和HIV-1发病风险的关联性研究,但是结论并不一致,所以本文用meta分析的方法对现有的研究进行分析,以探索rs11362基因多态性和HIV-1发病风险的关联性。方法搜索Pubmed网站、Web of Science网站、中国生物医学文献数据库(CBM)、Embase网站、维普、万方及中国知网数据库截至2022年9月30日之前发表的所有关于rs11362基因多态性和HIV-1发病风险关联性研究的文章,关联性强度用比值比(OR)和95%可信区间(CI)来评估。结果最终有9篇文章符合纳入标准。病例数总计2565例。显性模型显示,与携带GG基因型相比,携带AA/GA基因型增加了HIV-1的发病风险(OR=1.583,95%CI:1.054~2.376)。等位基因模型显示,和G等位基因相比,携带A等位基因增加了HIV-1的发病风险(OR=1.220,95%CI:1.013~1.469)。分层分析发现,同样的效应见于种族为混合人种的人群,包括显性模型(OR=2.337,95%CI:1.392~3.924)和等位基因模型(OR=1.465,95%CI:1.252~1.713)。结论rs11362基因多态性可能与HIV-1发病风险相关,需要进一步大样本研究及功能性实验结果来验证。Objective At present,there are many studies on the relationship between the gene polymorphism rs11362 and risk of HIV-1,but the conclusions are not consistent.So,we conducted a meta-analysis to explore the relationship between rs11362 and HIV-1.Methods Studies on the association between the gene polymorphism rs11362 and the risk of HIV-1 published before September 30,2022 were searched in PubMed Web of Science,China Biomedical Literature Database(CBM),Embase,VIP,Wanfang,and China knowledge Network database.The correlation was evaluated by OR and 95%confidence interval(CI).Results In total 9 articles involving 2565 cases met the inclusion criteria.In the dominant model,compared with carrying GG genotype,carrying AA/GA genotype increased the risk of HIV-1(OR=1.583,95%CI:1.054-2.376).In the allele model,carrying A allele increased the risk of HIV-1(OR=1.220,95%CI:1.013-1.469)compared with G allele.Stratified analysis showed that the same effect was found in people with mixed races,including dominant model(OR=2.337,95%CI:1.392-3.924)and allele model(OR=1.465,95%CI:1.252-1.713).Conclusion The gene polymorphism rs11362 might be associated with the risk of HIV-1,which needs to be verified by further large sample studies and functional experiments.

关 键 词：艾滋病病毒感染者 META分析 基因多态性 发病风险 

分 类 号：R512.91[医药卫生—内科学]