农药中间体2-氯-5-三氟甲基吡啶的合成  

Synthesis of pesticide intermediate 2-chloro-5-trifluoromethylpyridine

作　　者：戴耀 DA Yao(Dalian Join King Fine Chemical Co.,Ltd.,Dalian 116620,Liaoning,China)

机构地区：[1]大连九信精细化工有限公司,辽宁大连116620

出　　处：《农药》2023年第6期401-403,共3页Agrochemicals

摘　　要：[目的]以2,3-二氯-5-三氟甲基吡啶生产过程中过度氯代产生的副产物2,3,6-三氯-5-三氟甲基吡啶为原料制备2-氯-5-三氟甲基吡啶。[方法]以2,3,6-三氯-5-三氟甲基吡啶为原料,经过水解、加氢脱氯、氯代反应制备2-氯-5-三氟甲基吡啶,并进行工艺优化。[结果]最优反应条件下,工艺总收率57.7%,产品纯度为99.3%。[结论]该工艺开发出一条新的制备2-氯-5-三氟甲基吡啶的路线,变废为宝,原料成本低,适合工业化生产。[Aims]To synthesize 2-chloro-5-trifluoromethylpyridine with hyperchlorination byproduct 2,3,6-trichloro-5-trifluoromethylpyridine in the synthesis of 2,3-dichloro-5-trifluoromethyl pyridine as starting material.[Methods]2,3,6-Trichloro-5-trifluoromethylpyridine was used as starting material to synthesize 2-chloro-5-trifluoromethylpyridine via hydrolysis,hydrodechlorination,and chlorination reactions.[Results]Under the best reaction conditions,the total process yield was 57.7%,and the product purity was 99.3%.[Conclusions]A new technique for producing 2-chloro-5-trifluoromethylpyridine was developed,and the process is inexpensive and suitable for industrial manufacturing.Most significantly,it turns trash into treasure.

关 键 词：2 3-二氯-5-三氟甲基吡啶 2 3 6-三氯-5-三氟甲基吡啶 加氢脱氯 氯代 2-氯-5-三氟甲基吡啶 

分 类 号：TQ460.3[化学工程—制药化工]