透明质酸基微纳米凝胶的制备及生物医学应用  

Fabrication and Biomedical Application of Hyaluronic Acid Based Micro-and Nanogels

作　　者：钱雪丹 余伟江 付濬哲 王幽香[1] 计剑[1] Xuedan Qian;Weijiang Yu;Junzhe Fu;Youxiang Wang;Jian Ji(MOE Key Laboratory of Macromolecular Synthesis and Functionalization,Department of Polymer Science and Engineering,Zhejiang University,Hangzhou 310027,China)

机构地区：[1]教育部高分子合成与功能构造重点实验室,浙江大学高分子科学与工程学系,杭州310027

出　　处：《化学进展》2023年第4期519-525,共7页Progress in Chemistry

基　　金：国家重点研发计划项目(No.2020YFE0204400);国家自然科学基金项目(No.51873186)资助。

摘　　要：透明质酸是天然细胞外基质成分之一,具有良好的生物相容性、生物可降解性以及强大的保水能力。基于透明质酸的微纳米凝胶具有尺寸可调、易于修饰、柔软可变形且能保持结构完整的特点,不仅能满足大多数本体凝胶的应用需求,且因其小尺寸的特征又拥有独特的优势,因此在生物医用领域得到广泛应用。本文综述了透明质酸基微纳米凝胶的制备方式及其在生物医用领域的应用,并对其未来发展做出了展望。Hyaluronic acid is one of the primary components of the natural extracellular matrix,which has outstanding biocompatibility,biodegradability and excellent water retention capacity.Hyaluronic acid based micro-and nanogels have many desirable features of size adjustability,easy modification,deformability and structural integrity.They can not only meet most application requirements of bulk hydrogels,but also possess unique advantages due to small dimension,thus have been widely researched and used in biomedical field.This paper reviews the preparation methods and biomedical applications of hyaluronic acid based micro-and nanogels,and the future development of it is prospected.

关 键 词：透明质酸 微纳米凝胶 交联改性 生物医学应用 

分 类 号：TB324[一般工业技术—材料科学与工程]