人体核孔蛋白50的生物学特性及与病毒感染关系的研究进展  

Progress in the function of nucleoporin 50 and its relationship with viral infection

作　　者：林展武 向宽辉 Lin Zhanwu;Xiang Kuanhui(Department of Microbiology and Infectious Disease Center,School of Basic Medical Sciences,Peking University Health Science Center,Beijing 100191,China)

机构地区：[1]北京大学医学部基础医学院病原生物学系和感染病研究中心,北京100191

出　　处：《中华微生物学和免疫学杂志》2023年第5期389-396,共8页Chinese Journal of Microbiology and Immunology

基　　金：国家自然科学基金面上项目(81873579)。

摘　　要：核孔蛋白50 (nucleoporin 50, Nup50)参与构成核孔复合体的核篮结构, 主要包括N结构域(连接importin α)、F结构域(连接importin β)和R结构域(连接Ran), 其中N结构域包括两个importin α结合片段。目前关于Nup50在入核转运中的作用机制存在两种解释:"三相开关"模型和解聚回收模型。Nup50不仅参与物质运输, 还可调控基因组结构和基因表达。此外, Nup50参与病毒感染与复制过程, 临床研究表明, Nup50与乙型肝炎病毒和人类免疫缺陷病毒1的感染有关。目前关于Nup50与病毒感染的关系尚无深入研究, 本综述旨在通过总结Nup50生物学特性及其与病毒感染关系的研究进展, 为今后研究Nup50与病毒感染的关系提供线索和思路。Nucleoporin 50(Nup50)is a component of nuclear basket in nuclear pore complex.It includes three main domains:N domain binding to importinα,F domain binding to importinβand R domain binding to Ran.The N domain has two importinα-binding segments.There are mainly two models for explaining the role of Nup50 in nuclear import:tri-stable switch and disassemble-recycle model.Nup50 not only participates in nuclear import,but also regulates genome organization and gene expression.In addition,Nup50 is involved in the process of viral infection and replication.There is some evidence that Nup50 is related to hepatitis B virus and human immunodeficiency virus 1 infections.However,there are few researches on the relationship between Nup50 and viral infection.This article summarized the progress in the function of Nup50 and its relationship with viral infection,aiming to provide new ideas for the following in-depth study.

关 键 词：Nup50 入核转运 基因表达调控 病毒感染 乙型肝炎病毒 

分 类 号：R511[医药卫生—内科学]