光热核壳TiN@硼硅酸盐生物玻璃纳米颗粒的降解和矿化性能  

Photothermal Core-Shell TiN@Borosilicate Bioglass Nanoparticles:and Mineralization

作　　者：吴锐 张敏慧 金成韵 林健[1,2] 王德平[1,2] WU Rui;ZHANG Minhui;JIN Chenyun;LIN Jian;WANG Deping(School of Materials Science and Engineering,Tongji University,Shanghai 201804,China;Key Laboratory of Advanced Civil Engineering Materials,Ministry of Education,Tongji University,Shanghai 200092,China)

机构地区：[1]同济大学材料科学与工程学院,上海200092 [2]同济大学教育部土木工程先进材料重点实验室,上海200092

出　　处：《无机材料学报》2023年第6期708-716,共9页Journal of Inorganic Materials

基　　金：National Natural Science Foundation of China(51972232);National Key Research and Development Projects(2018YFC1106300)。

摘　　要：硼硅酸盐生物玻璃以其稳定的结构和优异的生物活性而受到广泛关注,但生物玻璃在矿化过程中活性呈现初期快而中后期慢的趋势,造成后期的活性降低。光热可加速生物玻璃降解,本研究制备了以氮化钛为核、生物玻璃(40SiO_(2)-20B_(2)O_(3)-36CaO-4P_(2)O_(5))为壳的复合生物玻璃,利用光热场干预生物玻璃的矿化过程。结果表明,生物玻璃具有显著的光热效应,光热能力随氮化钛掺杂量和激光功率密度的增加而提高;在体外浸泡中,近红外光辐照促进了生物玻璃的降解,浸泡7 d后模拟体液中钙、硼的含量分别增加12%~16%和8%~11%,加速了羟基磷灰石的生成;细胞增殖活性实验表明样品有良好的生物安全性。因此,光热场可促进生物玻璃降解和矿化,对周围细胞影响小,有望在保障初期生物安全的同时发挥调节作用。Borosilicate bioglass has attracted extensive attention due to its stable structure and excellent biological activity.However,the rate of its mineralization process is fast in the initial stage and slow in the middle and late stages,which limits the application of borosilicate bioglass.As an auxiliary method,the near-infrared(NIR)laser can accelerate the degradation of bioglass.Therefore,we prepared a core-shell borosilicate bioglass with titanium nitride as the core and bioglass(40SiO_(2)-20B_(2)O_(3)-36CaO-4P_(2)O_(5))as the shell,and used near-infrared laser regulation technology to intervene the mineralization process of the composite bioglass.The experimental results show that the core-shell bioglass exhibits a significant photothermal effect,and the photothermal ability increases with the increases of the doping amount of TiN NPs and the laser power density.During the in vitro immersion,near-infrared laser increased the degradation rate of bioglass.After immersion for 7 d,the contents of calcium and boron in the SBF are increased by 12%–16%and 8%–11%,respectively.Meanwhile,the formation efficiency of hydroxyapatite is significantly improved.Cell proliferation activity test shows that the sample has good biological safety.Therefore,near-infrared light can accelerate the degradation and mineralization of functional core-shell bioactive glass,which is expected to play a regulatory role.

关 键 词：硼硅酸盐生物活性玻璃 核壳结构 光热性能 矿化性能 

分 类 号：TQ171[化学工程—玻璃工业]