基于中医传承辅助平台挖掘《辨证录》中痹病内服方剂的组方配伍规律  

A data mining-based analysis of clinical medication rules of oral prescriptions for treatment of Bi-diseases in Syndrome Differentiation Record using traditional Chinese medicine inheritance support system

作　　者：王笑青 张丽丽 沙莎 柳维 崔亚鸽 朱久璞 张永红 WANG Xiaoqing;ZHANG Lili;SHA Sha;LIU Wei;CUI Yage;ZHU Jiupu;ZHANG Yonghong(Luoyang Orthopedic-Traumatological Hospital,Luoyang 471002,Henan,China)

机构地区：[1]河南省洛阳正骨医院/河南省骨科医院,河南洛阳471002

出　　处：《中医正骨》2023年第6期44-48,共5页The Journal of Traditional Chinese Orthopedics and Traumatology

摘　　要：目的:挖掘《辨证录》中痹病内服方剂的组方配伍规律。方法:收集《辨证录》中的痹病内服方剂,利用中医传承辅助平台(V2.5)对数据进行统计分析,挖掘方剂的组方配伍规律。结果:共收集到21首内服方剂,涉及65味中药,其中出现频次≥3的中药有20味,排在前5位的分别是白术、茯苓、肉桂、人参、薏苡仁。21首内服方剂的组方药物中,药性以温性出现频次最多,其次为平性、寒性;药味以甘味出现频次最多,其次为辛味和苦味;归经以脾经出现频次最多,其次为肺经、心经、肾经;出现频次≥6的药物组合有9个,排在前4位的为白术-茯苓、白术-肉桂、茯苓-肉桂、白术-茯苓-肉桂;核心药物组合2个,分别为甘草-白术-干姜、巴戟天-陈皮-薏苡仁。经聚类分析得到新处方1首,药物组成为白术、薏苡仁、陈皮、干姜、巴戟天、甘草。结论:《辨证录》中痹病内服方剂多采用性温、味甘、归脾经的药物;核心药物组合以健脾利湿、温阳散寒为主;以核心药物组合为基础聚类出的新方,仍符合祛湿温阳的治疗大法,可为临床用药提供参考,但其疗效有待进一步研究。Objective:To excavate the clinical medication rules of oral prescriptions for treatment of Bidiseases in Syndrome Differentiation Record.Methods:The oral prescriptions aimed at treating Bidiseases were extracted from the Syndrome Differentiation Record and were statistically analyzed by using traditional Chinese medicine inheritance support system(TCMISS)software(V2.5)for excavating the clinical medication rules.Results:Twentyone oral prescriptions were included in the final analysis,involving 65 Chinese herbs,among which 20 ones displayed a occurrence frequency of≥3,and the top 5 ones with high occurrence frequency included Atractylodis Macrocephalae Rhizoma,Poria(TCD),Cinnamomi Cortex,Ginseng Radix et Rhizoma and Coicis Semen in turn.Among the 21 oral prescriptions,the most frequently used Chinese herbs were those with a warm property,followed by the ones with a neutral property and a cold property,and the ones with sweet flavors were more preferred,followed by pungent and bitter flavors;and they mainly acted on the spleen meridians,followed by lung meridians,heart meridians and kidney meridians in turn.The occurrence frequency were≥6 in 9 herb combinations,and the top 4 ones with high occurrence frequency included Atractylodis Macrocephalae RhizomaPoria(TCD),Atractylodis Macrocephalae RhizomaCinnamomi Cortex,Poria(TCD)Cinnamomi Cortex and Atractylodis Macrocephalae RhizomaPoria(TCD)Cinnamomi Cortex.The cluster analysis on all the included Chinese herbs generated 2 core herb combinations,namely Glycyrrhizae Radix et Rhizoma(TCD)Atractylodis Macrocephalae RhizomaZingiberis Rhizoma and Morindae Officinalis RadixCitri Reticulatae PericarpiumCoicis Semen,and 1 new prescription were dug out,and its ingredients included Atractylodis Macrocephalae Rhizoma,Coicis Semen,Citri Reticulatae Pericarpium,Zingiberis Rhizoma,Morindae Officinalis Radix and Glycyrrhizae Radix et Rhizoma(TCD).Conclusion:The Chinese herbs are often the ones presented with warm property and sweet flavor and mainly act on spleen meridians in the

关 键 词：中医药学文献 数据挖掘 方剂构成 组方原则 聚类分析 痹证 《辨证录》 

分 类 号：R255.6[医药卫生—中医内科学]