环吡酮胺发用洗剂的制备及含量测定  

Preparation and Content Determination of Ciclopirox Olamine Hair Lotion

作　　者：石锦峰 李媛媛 徐旭辉 张帅 董自波 Shi Jinfeng;Li Yuanyuan;Xu Xuhui;Zhang Shuai;Dong Zibo(School of Pharmacy,Jiangsu Ocean University,Jiangsu,222005;Excellent Science and Technology Innovation Team of Jiangsu Provincial Department of Education,Jiangsu Marine Pharmaceutical Resources Development Engineering Research Center,Jiangsu,222005)

机构地区：[1]江苏海洋大学药学院,江苏222005 [2]江苏省教育厅高校优秀科技创新团队,海洋药用资源开发工程研究中心,江苏222005

出　　处：《当代化工研究》2023年第12期39-41,共3页Modern Chemical Research

摘　　要：制备环吡酮胺发用洗剂,并采用HPLC法测定环吡酮胺含量。采用WatersXTerraRMSC18(3.0mm×100mmcolumn)色谱柱,以0.096%的乙二胺四乙酸二钠溶液-冰醋酸(750:0.1)为流动相A,乙腈为流动相B,采用梯度洗脱,流速0.7mL/min,检测波长为304nm,柱温:30℃,进样量:20μL。结果表明,环吡酮胺在0.06~0.09mg/mL范围内,浓度与峰面积的线性关系良好(r=0.9938),回收率、精密度符合要求,空白辅料对环吡酮胺的测定没有干扰,含量测定方法简便、灵敏、准确。Preparation of ciclopirox olamine hair lotion,determination of ciclopirox olamine content by HPLC.A Waters X TerraR MS C18(3.0 mm×100 mm column)chromatographic column was used,0.096%disodium ethylenediaminetetraacetate solution-glacial acetic acid(750:0.1)was used as mobile phase A,acetonitrile was used as mobile phase B,and gradient elution was used.The flow rate was 0.7 mL/min,the detection wavelength was 304 nm,the column temperature:30°C,and the injection volume:20μL.The results showed that ciclopirox olamine was in the range of 0.06~0.09 mg/mL,and the linear relationship between the concentration and the peak area was good(r=0.9938),and the recovery and precision meet the requirements.Blank excipients did not interfere with the determination of ciclopirox olamine,and the content determination method is simple,sensitive and accurate.

关 键 词：环吡酮胺 HPLC 制备 含量测定 

分 类 号：R927.2[医药卫生—药学]