血清糖原合成激酶3β、脑源性神经营养因子及血糖波动与老年2型糖尿病患者轻度认知功能障碍相关性的研究  

Association of serum GSK-3β,BDNF,blood glucose fluctuation with mild cognitive impairment in elderly type 2 diabetic patients

作　　者：何苗苗 孙娟 李小霜 于洪恩 张珍华 HE Miaomiao;SUN Juan;LI Xiaoshuang(The First Clinical Medical College of Xuzhou Medical University,Xuzhou 221004,China)

机构地区：[1]徐州医科大学第一临床医学院,221004 [2]徐州医科大学附属医院内分泌科

出　　处：《中国糖尿病杂志》2023年第5期350-354,共5页Chinese Journal of Diabetes

基　　金：江苏省徐州市科学技术局社会发展项目(KC15SH089)。

摘　　要：目的探讨血清糖原合成激酶3β(GSK-3β)、脑源性神经营养因子(BDNF)及血糖波动与老年T2DM患者轻度认知功能障碍(MCI)的相关性。方法选取2021年5月至2022年1月于徐州医科大学附属医院内分泌科住院治疗的老年T2DM患者121例,根据蒙特利尔认知评估量表(MoCA)及简易精神状态评估量表(MMSE)评分,分为认知功能正常的T2DM组(n=68)及MCI组(n=53)。结果与T2DM组比较,MCI组年龄、DM病程、MAGE、Scr、GSK-3β升高(P<0.05),受教育程度、TIR、MoCA评分、MMSE评分、BDNF降低(P<0.05)。Logistic回归分析显示,TIR、MAGE、Scr、GSK-3β、BDNF是老年T2DM患者MCI的影响因素。结论血清GSK-3β、BDNF及BG波动与老年T2DM患者MCI相关,GSK-3β及BDNF有望成为T2DM患者早期筛查MCI的血清标志物,TIR、MAGE可作为新一代控糖指标。Objective To investigate the association between serum glycogen synthase kinase 3β(GSK-3β),brain-derived neurotrophic factor(BDNF),blood glucose fluctuation and mild cognitive impairment(MCI)in elderly patients with type 2 diabetes mellitus(T2DM).Methods 121 elderly T2DM patients who were hospitalized in the endocrinology department of Xuzhou Medical University Affiliated Hospital from May 2021 to January 2022 were selected and divided into cognitive normal group(T2DM,n=68)and MCI group(n=53)based on the scores of Montreal Cognitive Assessment Scale(MoCA)and Minimal Mental State Assessment Scale(MMSE).Results Compared with T2DM group,age,DM duration,MAGE,Scr and GSK-3βincreased in MCI group(P<0.05),while education level,TIR,MoCA and MMSE scores,and BDNF decreased(P<0.05).Logistic regression analysis showed that TIR,MAGE,Scr,GSK-3β,BDNF were influencing factors for MCI in elderly T2DM patients.Conclusion Serum GSK-3β,BDNF and blood glucose fluctuations are associated with MCI in elderly T2DM patients,and they are expected to become serum markers for early screening.TIR and MAGE can be used as new indicators for blood glucose control.

关 键 词：糖尿病 2型 轻度认知功能障碍 糖原合成激酶3β 脑源性神经营养因子 血糖波动 

分 类 号：R587.2[医药卫生—内分泌] R749.1[医药卫生—内科学]