Ⅱ型免疫反应在斑秃中的研究进展  

Research Progress of TypeⅡImmunity in Alopecia Areata

作　　者：闫昕 叶艳婷[1] YAN Xin;YE Yanting(Department of Dermatology,the First Affiliated Hospital,Sun Yat-Sen University,Guangzhou 510030,China)

机构地区：[1]中山大学附属第一医院皮肤科,广东广州510030

出　　处：《中国皮肤性病学杂志》2023年第5期601-604,共4页The Chinese Journal of Dermatovenereology

基　　金：国家青年自然科学基金项目(81903236)。

摘　　要：既往认为斑秃是一种以Ⅰ型免疫反应为主的自身免疫性脱发疾病,然而近年来,不断有研究发现Ⅱ型免疫反应,如Ⅱ型细胞因子、Ⅱ型免疫反应相关细胞同样参与到斑秃的发生发展,且与其易感性、严重性和迁延性存在密切联系,但具体作用仍然不清楚。本综述将从与斑秃发病有关的Ⅱ型免疫反应的角度进行阐述,从细胞因子到细胞水平进一步阐明Ⅱ型免疫反应对斑秃的影响,有助于未来为斑秃患者提供精准治疗。Alopecia areata(AA)was considered to be a typeⅠautoimmune alopecia disease.However,in recent years,continuous studies have found that typeⅡimmune response,such as typeⅡcytokines and typeⅡimmune response-related cells,are also involved in the occurrence and development of AA.Although typeⅡimmune responses are closely related to susceptibility,severity and duration of AA,its specific role is still unclear.This review will elaborate the typeⅡimmune response related to the occurrence of AA,and further clarify the influence of typeⅡimmunity on AA,which is conducive to providing accurate treatment for AA patients in the future.

关 键 词：斑秃 Ⅱ型免疫反应 Ⅱ型细胞因子 IGE 嗜酸性粒细胞 肥大细胞 树突状细胞 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]