三种色胺类物质诱导的小鼠条件性位置偏爱研究  

Research on the Conditioned Place Preference Induced by Three Tryptamines in Mice

作　　者：李楠[1,2] 李锋 魏佳韵 乔艳玲 李香豫 王优美 徐鹏 狄斌[1,2] LI Nan;LI Feng;WEI Jiayun;QIAO Yanling;LI Xiangyu;WANG Youmei;XU Peng;DI Bin(China Pharmaceutical University,Nanjing 210009,Jiangsu,China;Ofice of China National Narcotics Control Commission-China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control,Beijing 100193,China;Key Laboratory of Drug Monitoring and Control,Drug Intelligence and Forensic Center,Ministry of Public Security,Bejing 100193,China)

机构地区：[1]中国药科大学,江苏南京210009 [2]国家禁毒委员会办公室-中国药科大学禁毒关键技术联合实验室,北京100193 [3]毒品监测管控与禁毒关键技术公安部重点实验室,公安部禁毒情报技术中心,北京100193

出　　处：《中国药物滥用防治杂志》2023年第5期737-740,749,共5页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:研究三种色胺类物质AMT、5-MeO-AMT和5-MeO-DiPT诱导的小鼠条件性位置偏爱(CPP)行为.方法:通过CPP实验方法对AMT、5-MeO-AMT和5-MeO-DiPT的奖赏效应进行评估,采用腹腔注射方式,以MDMA为阳性对照,观察不同剂量的AMT、5-MeO-AMT和5-MeO-DiPT小鼠训练5 d后获得的CPP分数.结果:CPP实验结果显示,MDMA在给药剂量为3 mg/kg时开始能够剂量依赖性地诱导小鼠产生CPP行为,AMT和5-MeO-AMT在给药剂量为30 mg/kg时能够诱导小鼠产生CPP行为,在本研究剂量范围内,5-MeO-DiPT不能诱导小鼠的CPP行为.结论:与MDMA相比,这三种色胺类物质AMT、5-MeO-AMT和5-MeO-DiPT诱导小鼠产生CPP行为的奖赏效应强度较弱,提示其精神依赖性可能较弱,其具体作用机制有待于进一步研究.Objective:To investigate the conditioned place preference(CPP)behavior induced by three tryptamines AMT,5-MeOAMT and 5-MeO-DiPT in mice.Methods:In this paper,the rewarding effects of AMT,5-MeO-AMT and 5-MeO-DiPT were tested by the CPP test.MDMA was used as the positive control.Intraperitoneal injections of AMT,5-MeO-AMT and 5-MeO-DiPT at different doses were used to observe the CPP scores of miceobtained after 5 days of training.Results:The results of the CPP test showed that MDMA started to dose-dependently induce CPP behavior in mice at the dose of 3 mg/kg,while AMT and 5-MeO-AMT started to induce CPP behavior in mice at the dose of 30 mg/kg.5-MeO-DiPT failed to induce CPP behavior in mice within the range of doses in this experiment.Conclusion:The rewarding effects of CPP behavior induced by the three tryptamines AMT,5-MeO-AMT and 5-MeO-DiPT are weaker than MDMA,suggesting that their psychological dependence may be weaker.The specific mechanism of them needs to befurther investigated.

关 键 词：色胺类物质 条件性位置偏爱 精神依赖性 奖赏效应 

分 类 号：R965[医药卫生—药理学]