慢性肾脏病患者钙磷代谢、NT-proBNP、Cys-C水平与心力衰竭发生的关系  

Relationship between calcium and phosphorus metabolism,NT-proBNP,Cys-C levels and the occurrence of heart failure in patients with chronic kidney disease

作　　者：沈冬明[1] 严春霞[1] SHEN Dong-ming;YAN Chun-xia(Department of Clinical Laboratory,Luodian Hospital of Shanghai Baoshan District,Shanghai 201908,CHINA)

机构地区：[1]上海市宝山区罗店医院检验科,上海201908

出　　处：《海南医学》2023年第12期1762-1765,共4页Hainan Medical Journal

摘　　要：目的分析慢性肾脏病(CKD)患者钙磷代谢、N端前脑钠肽(NT-proBNP)、血胱抑素C(Cys-C)水平与心力衰竭发生的关系。方法回顾性分析2020年6月至2021年10月上海市宝山区罗店医院收治的130例CKD患者的临床资料,将其中68例出现心力衰竭的患者作为观察组1,62例未出现心力衰竭的患者作为观察组2,选取同期在我院体检的70例健康者作为对照组。比较三组受试者的钙磷代谢指标[血磷(P)、血钙(Ca)、甲状旁腺激素(PTH)]、NT-proBNP、Cys-C及心功能指标[静息心率(HR)、左室射血分数(LVEF)、心搏出量(SV)、每分排血量(CO)],并采用Pearson相关性分析CKD患者钙磷代谢、NT-proBNP、Cys-C水平与心力衰竭发生的关系。结果观察组1患者的P、Ca、PTH、NT-proBNP、Cys-C水平分别为(5.24±1.12)mmol/L、(7.02±1.42)mmol/L、(189.34±41.45)pg/mL、(387.98±52.26)pmol/L、(12.07±3.13)mg/L,明显高于观察组2的(3.01±0.53)mmol/L、(4.01±0.91)mmol/L、(74.34±18.32)pg/mL、(193.14±26.47)pmol/L、(7.34±1.82)mg/L和对照组的(1.27±0.25)mmol/L、(2.01±0.37)mmol/L、(32.98±7.26)pg/mL、(103.82±16.03)pmol/L、(3.27±0.61)mg/L,而观察组2的上述各项指标明显高于对照组,差异均有统计学意义(P<0.05);观察组1患者的HR水平为(84.92±9.14)次/min,明显高于观察组2的(76.21±5.28)次/min和对照组的(58.38±8.27)次/min,而观察组2又明显高于对照组,差异均有统计学意义(P<0.05);观察组1患者的LVEF、SV、CO水平分别为(46.23±5.21)%、(41.28±5.27)mL、(3.12±0.52)L/min,明显低于观察组2的(57.43±5.09)%、(54.11±3.95)m L、(4.92±0.95)L/min和对照组的(63.18±4.27)%、(67.28±5.38)m L、(7.12±1.18)L/min,而观察组2患者的上述各项指标明显低于对照组,差异均有统计学意义(P<0.05);经Pearson相关性分析结果显示,HR与P、Ca、PTH、NT-proBNP、Cys-C均呈正相关(P<0.05);LVEF、SV、CO与P、Ca、PTH、NT-proBNP、Cys-C均呈负相关(P<0.05)。结论CKD患者钙磷代谢及NT-proBNP、CyObjective To analyze the relationship between calcium and phosphorus metabolism,N-terminal forebrain natriuretic peptide(NT-proBNP),blood cystatin C(Cys-C)levels and the occurrence of heart failure in patients with chronic kidney disease(CKD).Methods The clinical data of 130 CKD patients admitted to Luodian Hospital of Shanghai Baoshan District from June 2020 to October 2021 were retrospectively analyzed.Among them,68 patients with heart failure were selected as observation group 1,and 62 patients without heart failure were selected as observation group 2.Seventy healthy individuals who underwent physical examination in the hospital during the same period were selected as control group.The calcium and phosphorus metabolism indicators[blood phosphorus(P),blood calcium(Ca),parathyroid hormone(PTH)],NT-proBNP,Cys-C,and cardiac function indicators[resting heart rate(HR),left ventricular ejection fraction(LVEF),cardiac output(SV),and output per minute(CO)]of the three groups of subjects were compared.The relationship between calcium and phosphorus metabolism,NT proBNP,Cys-C levels and the occurrence of heart failure in CKD patients was analyzed using Person correlation.Results The levels of calcium and phosphorus metabolism indexes(P,Ca,PTH),NT-proBNP,and Cys-C in observation group 1 were(5.24±1.12)mmol/L,(7.02±1.42)mmol/L,(189.34±41.45)pg/mL,(387.98±52.26)pmol/L,(12.07±3.13)mg/L,which were significantly higher than(3.01±0.53)mmol/L,(4.01±0.91)mmol/L,(74.34±18.32)pg/mL,(193.14±26.47)pmol/L,(7.34±1.82)mg/L of the observation group 2 and(1.27±0.25)mmol/L,(2.01±0.37)mmol/L,(32.98±7.26)pg/mL,(103.82±16.03)pmol/L,(3.27±0.61)mg/L in the control group,with statistically significant difference(P<0.05).The above indexes in observation group 2 were significantly higher than those in the control group(P<0.05).HR level of observation group 1 was(84.92±9.14)times/min,which was significantly higher than(76.21±5.28)times/min of observation group 2 and(58.38±8.27)times/min of the control group,and the level of obser

关 键 词：慢性肾脏病 钙磷代谢 N端前脑钠肽 血胱抑素C 心力衰竭 相关性 

分 类 号：R692[医药卫生—泌尿科学]