NK2同源框蛋白-1在胚胎反复种植失败中的研究进展  

Research progress of NK2 homeobox protein 1 in recurrent implantation failure of embryos

作　　者：匡云琪 蔡金凤[2] 姚颖杰[2] 寸金涛 肖彭莹(综述)[2] 张若鹏(审校) KUANG Yun-qi;CAI Jin-feng;YAO Ying-jie;CUN Jin-tao;XIAO Peng-ying;ZHANG Ruo-peng(Clinical Medical College,Dali University,Dali 671000,Yunnan,CHINA;Reproductive Medicine Center,Kunming Maternal and Child Health Hospital,Kunming 650118,Yunnan,CHINA;Postgraduate Training Base,Kunming Maternal and Child Health Hospital,Dali University,Kunming 650118,Yunnan,CHINA)

机构地区：[1]大理大学临床医学院,云南大理671000 [2]昆明市妇幼保健院生殖医学中心,云南昆明650118 [3]大理大学昆明市妇幼保健院研究生培养基地,云南昆明650118

出　　处：《海南医学》2023年第12期1802-1806,共5页Hainan Medical Journal

基　　金：国家自然科学基金(编号:82260309、81860271)。

摘　　要：胚胎着床是一个复杂的生理过程,除了拥有优质胚胎以外,还需要良好的子宫内膜容受性以及母胎之间的协调对话。NK2同源框蛋白-1(NK2 homeobox protein 1,NKX2-1)是一种含有同源结构域的转录因子。最近研究表明NKX2-1可以通过调控一系列细胞因子及黏附分子的作用影响胚胎着床过程,从而导致反复种植失败(recurrent implantation failure,RIF)的发生。本文就NKX2-1的结构、功能及其与反复种植失败之间的关系做一综述,并对今后研究方向作一展望,以期对RIF的发生机制和防治策略有更深入的了解。Embryo implantation is a complex physiological process.It requires good endometrial tolerance and a coordinated dialogue between mother and fetus,in addition to the availability of good quality embryos.NK2 homeobox protein 1(NKX2-1)is a transcription factor containing a homologous structural domain.Recent studies have shown that NKX 2-1 can affect the embryonic implantation process by regulating a series of cytokines and adhesion molecules,thus leading to the occurrence of recurrent implantation failure(RIF).This paper summarizes the structure and function of NKX2-1 and its relationship with RIF,and provides an outlook on the future research directions in order to gain a better understanding of the mechanisms and prevention strategies of RIF.

关 键 词：NK2同源框蛋白-1 反复种植失败 子宫内膜容受性 黏附分子 

分 类 号：R715[医药卫生—妇产科学]