张家口地区婴幼儿维生素D营养状况分析  

Analysis of vitamin D nutritional status of infants in Zhangjiakou

作　　者：尉全平[1] 翟洪然 侯凤香[1] 苏琴 付晓康 杨建宝[3] 孙子梅[1] YU Quanping;ZHAI Hongran;HOU Fengxiang(Department of Pediatrics,the Second Affiliated Hospital of Hebei North University,Hebei,Zhangjiakou 075100,China;不详)

机构地区：[1]河北北方学院附属第二医院儿科,河北省张家口市075100 [2]河北北方学院附属第二医院消化内镜中心,河北省张家口市075100 [3]河北北方学院附属第二医院检验科,河北省张家口市075100

出　　处：《河北医药》2023年第9期1406-1408,1413,共4页Hebei Medical Journal

基　　金：张家口市科技计划财政资助项目(编号:1911022D)。

摘　　要：目的通过检测血清25-羟维生素D[25-hydroxyvitamin D,25(OH)D]水平,了解张家口地区各个年龄段婴幼儿在不同季节的维生素D营养状况,分析影响因素,为制定儿童维生素D补充策略提供参考。方法采用分层随机抽样方法,时间跨度为4个季节:冬季(12月~次年2月)、春季(3~5月)、夏季(6~8月)、秋季(9~11月),分为3个年龄组:≤1岁组、>1~2岁组、>2~3岁组,在每个季节中每个年龄组抽取40例,酶联免疫法测定血清25(OH)D水平,对数据进行分析。结果张家口地区婴幼儿25(OH)D水平为(21.66±7.82)ng/ml,维生素D不足比例为11.88%,维生素D缺乏比例为18.96%,维生素D严重缺乏比例为1.67%,未检出维生素D过量。男童与女童的25(OH)D水平及维生素D缺乏率比较,差异无统计学意义(P>0.05)。婴幼儿25(OH)D水平总体来说夏季最高,秋季次之,冬春两季比较差异无统计学意义(P>0.05)。≤1岁组儿童4个季节的25(OH)D水平比较差异无统计学意义(P>0.05);>1~2岁组儿童夏季25(OH)D水平最高,冬季最低,春秋两季比较差异无统计学意义(P>0.05);>2~3岁组儿童夏季25(OH)D水平最高,秋季次之,冬春两季比较差异无统计学意义(P>0.05)。≤1岁组和>2~3岁组儿童25(OH)D水平均高于>1~2岁组;3组儿童规律补充维生素D的比例,≤1岁组最高,>1~2岁组次之,>2~3岁组最低,差异有统计学意义(P<0.05)。结论张家口地区婴幼儿维生素D营养状况需进一步改善,建议增加户外活动时间,尤其是婴儿户外活动,参考季节等因素,在整个婴幼儿期均需注意维生素D制剂的补充。Objective To investigate the vitamin D nutritional status of infants at different ages in different seasons in Zhangjiakou by detecting the serum 25-hydroxyvitamin D(25[OH]D)levels,and to analyze the influencing factors,thus providing references for the development of vitamin D supplementation strategies for infants in this area.Methods Stratified by the seasons of winter(from December to February of the next year),spring(from March to May),summer(from June to August)and autumn(from September to November),and ages(≤1 year old group,1-2 years old group and 2-3 years old group),25(OH)D levels in 40 children from Zhangjiakou who were selected by a stratified random sampling method of each group were measured by enzyme linked immunosorbent assay(ELISA).Results The mean 25(OH)D level of infants and young children in Zhangjiakou was(21.66±7.82)ng/ml.The proportion of vitamin D insufficiency,deficiency and severe deficiency in them was 11.88%,18.96%and 1.67%,respectively,and hypervitaminosis D was not detected.There was no significant difference in the vitamin D insufficiency between male and female children(P>0.05).The mean 25(OH)D level in infants remained the highest in summer,followed by autumn,which was similar in spring and winter(P>0.05).There was no significant difference in the mean 25(OH)D level of≤1 year old group in the four seasons(P>0.05).The mean 25(OH)D level in 1-2 years old group remained the highest in summer and lowest in winter,which was similar in spring and autumn(P>0.05).The mean 25(OH)D level in 2-3 years old group remained the highest in summer,followed by autumn,which was similar in spring and winter(P>0.05).The mean 25(OH)D level in≤1 year old group and 2-3 years old group was significantly higher than that in 1-2 years old group(P<0.05).The proportion of children with a regular supplementation of vitamin D was the highest in≤1 year old group,followed by 1-2 years old group and 2-3 years old group,and with statistically significant difference(P<0.05).Conclusion The vitamin D nutritio

关 键 词：维生素D 营养状况 婴幼儿 25-羟维生素D 

分 类 号：R195[医药卫生—卫生统计学]