沙库巴曲缬沙坦对高血压左心房增大患者的疗效分析  

Curative effect of sakubatril-valsartan in patients with hypertensive left atrial enlargement

作　　者：葛慧娟 庄晓赛 张婷 解慧新 郭影 张婷婷 宁彬 Ge Huijuan;Zhuang Xiaosai;Zhang Ting;Xie Huixin;Guo Ying;Zhang Tingting;Ning Bin(Department of Cardiovascular Medicine,People's Hospital of Fuyang City,Anhui Province,Fuyang 236000,China;不详)

机构地区：[1]安徽省阜阳市人民医院心血管内科,阜阳236000

出　　处：《中国循证心血管医学杂志》2023年第3期322-324,328,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

基　　金：安徽省蚌埠医学院自然科学类科技项目(2020byzd354)。

摘　　要：目的探讨沙库巴曲缬沙坦对高血压左心房增大(LAE)患者的疗效。方法选取2021年1月至9月于安徽省阜阳市人民医院心血管内科就诊及住院的1级、2级高血压合并LAE患者172例,其中男性85例,女性87例,年龄43~77岁,平均年龄(67.5±8.3)岁,包括行心房颤动(房颤)导管消融术患者92例,入选时均为窦性心律。根据患者用药不同分为三组:沙库巴曲缬沙坦组(A组,n=57),贝那普利组(B组,n=59),缬沙坦组(C组,n=56),随访9个月,比较三组患者在左心房逆转、房颤发生率、血压达标率方面的差异及临床疗效。结果比较三组患者在年龄、性别、高血压级别、LAE程度、房颤类型及合并糖尿病、冠心病、高脂血症等一般资料比较均无统计学差异(P>0.05),三组患者治疗前后自身对比LAE逆转、血压控制情况等方面,效果改善均具有统计学差异(P均<0.05)。治疗后三组比较,相比于B组和C组,A组LAE逆转、房颤导管消融术后复发(房颤复发)、高血压控制达标方面更优,差异有统计学意义(P<0.05)。结论沙库巴曲缬沙坦治疗高血压LAE患者,降压效果好、血压控制达标率高,可改善左心房重构、减少房颤复发率。Objective To investigate the curative effect of sakubatril-valsartan in patients with hypertensive left atrial enlargement(LAE).Methods The patients with grade I or grade II hypertension complicated by LAE(n=172,including 85 male cases and 87 female cases,aged from 43 to 77 and average age=67.5±8.3)were chosen from Department of Cardiovascular Medicine in People’s Hospital of Fuyang City from Jan.2021 to Sept.2021.Among these patients,there were 92 patients with sinus rhythm received catheter ablation.All patients were divided,according to medicinal administration,into group A(treated with sakubatril-valsartan,n=57),group B(treated with benazepril,n=59)and group C(treated with valsartan,n=56),and all groups were followed up for 9 months.The differences in left atrial reversal,incidence of atrial fibrillation(AF)and blood pressure compliance rate and clinical efficacy were compared among 3 groups.Results The comparison in the general material showed no statistical differences among 3 groups(P>0.05),including age,gender,hypertension grades,LAE severity,AF types and complicated by diabetes,coronary heart disease and hyperlipidemia.The comparison in improvements of LAE reversal and blood pressure control showed there were statistical differences among 3 groups before and after treatment(P<0.05).The comparison among 3 groups showed that LAE reversal,AF recurrence after catheter ablation and compliance of hypertension controlling were better in group A than those in groups B and C(P<0.05).Conclusion Sakubatril-valsartan has higher antihypertensive effect and hypertension compliance rate,and can relieve left atrial remodeling and reduce AF recurrence rate in patients with hypertensive LAE.

关 键 词：沙库巴曲缬沙坦 高血压 左心房增大 心房颤动 导管消融术 

分 类 号：R544.1[医药卫生—心血管疾病]