结肠靶向给药系统在粪菌移植中的应用  

Application of colon targeted drug delivery system in fecal microbiota transplantation

作　　者：陈吉含(综述) 金黑鹰[1] 刘建磊 肖相楠(审校) CHEN Jihan;JIN Heiying;LIU Jianlei;XIAO Xiangnan(Department of Anus-intestines,the Second Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210017,China)

机构地区：[1]南京中医药大学第二附属医院肛肠科,江苏南京210017

出　　处：《现代医药卫生》2023年第12期2090-2095,共6页Journal of Modern Medicine & Health

基　　金：江苏省中医药科技发展计划面上项目(MS2021030)。

摘　　要：粪菌移植(FMT)对多种疾病有独特的疗效,其常见的治疗途径主要有口服、鼻肠管、结肠镜、灌肠等。其中口服服用方便,多次服用相对损伤小,但是口服粪菌如果在胃或小肠中崩解会影响FMT效果。结肠靶向给药系统(CTDDS)使药物更准确地作用于结肠,能提高治疗效果,减少毒副作用。CTDDS除了传统的pH敏感型、时滞型、酶触发型、压力依赖型等外,随着研究的深入还发展出了磁驱动型、配(受)体介导型、纳米药物型等。近年来一些研究将二者结合,使用CTDDS进行FMT,取得了一定的疗效,该文系统介绍了CTDDS在FMT中的应用。Fecal microbiota transplantation(FMT)has a unique therapeutic effect on a variety of diseases,and its common therapeutic approaches mainly include oral administration,nasointestinal tube,colonoscopy,enema and etc.Among them,because of its convenience in taking,the injury of taking oral administration multiple times is relatively small.But oral fecal bacteria will affect the FMT effect if it disintegrates in the stomach or small intestine.Colon targeted drug delivery system(CTDDS)enables drugs to act on the colon more accurately,which can improve the therapeutic effect and reduce the adverse reactions.In addition to the traditional pH-sensitive,time-delayed,enzyme-triggered,pressure-dependent and so on,CTDDS has developed into magnetic-driven,ligand(acceptor)-mediated,nano-drug and so on with the deepening of research.In recent years,some studies have combined them and used CTDDS to carry out FMT,which has achieved certain effects.This paper systematically introduces the application of CTDDS in FMT.

关 键 词：结肠靶向给药系统 粪菌移植 口服粪菌胶囊 综述 

分 类 号：R945[医药卫生—微生物与生化药学] R452[医药卫生—药剂学]