妊娠晚期孕妇外周血维生素及微量元素水平与新生儿生长发育关系  

Correlation between the levels of vitamins and trace elements in the peripheral blood of pregnant women during the third trimester of pregnancy and their neonatal growth and development

作　　者：何云霄[1] 王丹丹[2] 张鸿飞[1] HE Yunxiao;WANG Dandan;ZHANG Hongfei(Tiantai Hospital Traditional Chinese Medicine,Tiantai,Zhejiang Province,317200;Taizhou Hospital,ZhejiangProvince)

机构地区：[1]浙江省天台县中医院,317200 [2]浙江省台州医院

出　　处：《中国计划生育学杂志》2023年第6期1347-1351,共5页Chinese Journal of Family Planning

摘　　要：目的:探讨妊娠晚期孕妇外周血维生素及微量元素水平及与新生儿生长发育关系。方法:收集2019年1月-2021年12月在本院住院分娩且发生胎儿生长受限(FGR)孕妇45例为FGR组,同期胎儿健康孕妇45例为对照组,均于孕晚期测定外周血维生素A(Vit A)、Vit B12、Vit C、Vit E,以及叶酸(FA)、同型半胱氨酸(Hcy)及微量元素钙、铁、锌、镁、铜水平,测定新生儿出生体质量、身长、头围、婴儿体重指数(PI)和出生10min Apar评分,FGR组血清维生素及微量元素水平与新生儿生长发育参数的相关性用Pearson线性相关分析。结果:FGR组血清Vit A、Vit B12、Vit C、Vit E、FA、钙、铁、锌、镁、铜水平均低于对照组,Hcy水平高于对照组(均P<0.05);FGR组外周血Vit A、Vit B12、Vit C、Vit E、FA、钙、铁、锌、镁、铜与新生儿出生体质量、身长、头围、PI和出生10min Apar评分均呈正相关,Hcy与新生儿出生体质量、身长、头围、PI和Apar评分均呈负相关(P<0.05)。结论:FGR孕妇妊娠晚期存在一定程度的维生素及微量元素缺乏,并伴有FA降低和Hcy升高,且指标水平与新生儿出生指标不良均有一定关系,加强孕前上述指标监测有助于FGR早期评估与干预。Objective:To investigate the correlation between the levels of vitamins and trace elements in the peripheral blood of pregnant women during the third trimester of pregnancy and their neonatal growth and development.Methods:45pregnant women with fetal growth restriction(FGR)were enrolled in study group,and 45pregnant women without FGR were included in control group from January 2019to December 2021.The levels of vitamin A(Vit A),vitamin B12(Vit B12),vitamin C(Vit C),vitamin E(Vit E),folic acid(FA),homocysteine(Hcy),and trace elements(calcium,iron,zinc,magnesium,copper)in the peripheral blood of the women in the two groups during the third trimester of pregnancy were detected.The neonatal birth body mass,length,head circumference,ponderal index(PI),and Apar in 10min after born were measured.The correlation between the levels of serum vitamins and trace elements of the women in the study group and the parameters of their neonatal growth and development was analyzed by Pearson correlation analysis.Results:The serum levels of Vit A,Vit B12,Vit C,Vit E,FA,calcium,iron,zinc,magnesium,and copper of the women in the study group were significantly lower than those of the women in the control group,while the Hcy levelc2ᦈof the women in the study group was significantly higher than that of the women in the control group(all P<0.05).In the study group,the levels of Vit A,Vit B12,Vit C,Vit E,FA,calcium,iron,zinc,magnesium,and copper in peripheral blood of the women were significantly positively correlated with their neonatal birth weight,body length,head circumference,PI,and 10min Apar score,and the Hcy level of the women was significantly negatively correlated with their neonatal birth weight,body length,head circumference,PI,and Apar scores(P<0.05).Conclusion:There is a certain degree deficiency of vitamins and trace elements of the pregnant women during the third trimester of pregnancy,accompanied by the decreased FA level and the increased Hcy level,which may have a certain relationship with their neonatal adverse birth

关 键 词：妊娠晚期 维生素 微量元素 胎儿宫内生长受限 新生儿出生指标不良 相关性 

分 类 号：R714.5[医药卫生—妇产科学]