妊娠期糖尿病患者血清NRG4、HGF、SAA与糖脂代谢、不良妊娠结局关系  

Expressions of serum neuromodulatory protein 4,hepatocyte growth factor,and amyloid A of women with gestational diabetes mellitus and their associated with the glucose and lipid metabolism indexes levels and the adverse pregnancy outcomes

作　　者：孔成 邱红 朱月蓉 王兰 余美萱 杨帆 KONG Cheng;QIU Hong;ZHU Yuerong;WANG Lan;YU Meixuan;YANG Fan(General Hospital of Eastern Theater Command of Qinghuai District,Nanjing,Jiangsu Province,210022;Nanjing Red Cross Hospital,Nanjing,Jiangsu Province)

机构地区：[1]东部战区总医院秦淮医疗区,南京210022 [2]江苏省南京市红十字医院

出　　处：《中国计划生育学杂志》2023年第6期1425-1429,共5页Chinese Journal of Family Planning

摘　　要：目的:探讨妊娠期糖尿病(GDM)患者血清神经调节蛋白4(NRG4)、肝细胞生长因子(HGF)、血清淀粉样蛋白A(SAA)表达及与糖脂代谢、不良妊娠结局关系。方法:收集2021年1月-2022年1月本院收治的GDM患者72例为GDM组,产前检查健康孕妇50例为对照组,检测两组血清NRG4、HGF、SAA水平,空腹血糖(FPG)、餐后1h血糖(1hPG)、餐后2h血糖(2hPG)、总胆固醇(TC)、甘油三脂(TG)、载脂蛋白A(apoA)、高密度脂蛋白(HDL)和低密度脂蛋白(LDL)糖脂代谢指标水平,评估两组妊娠结局,根据妊娠结局将GDM组分为妊娠不良组和妊娠良好组,采用Pearson相关性分析。结果:GDM组NRG4、HGF、HDL-C水平均低于对照组,SAA、TG、TC、LDL-C、apoA、FPG、1hPG、2hPG、FINS、HOMA-IR水平均高于对照组;Pearson相关性分析,GDM患者血清NRG4、HGF、SAA与TG、LDL、HDL、apoA、FPG、2hPG、FINS、HOMA-IR均存在相关性(均P<0.05)。不良妊娠结局发生率GDM组(61.1%)高于对照组(8.0%),妊娠良好组血清NRG4、HGF水平均高于妊娠不良组,SAA低于妊娠不良组(均P<0.05);Pearson相关性分析,血清NRG4、HGF、SAA表达与不良妊娠结局均存在相关性(P<0.05)。结论:妊娠中晚期GDM孕妇NRG4、HGF、SAA血清水平发生异常,且表达与糖脂代谢指标和不良妊娠结局均存在相关性。Objective:To investigate the expressions of serum neuromodulatory protein 4(NRG4),hepatocyte growth factor(HGF),and amyloid A(SAA)pregnant women with gestational diabetes mellitus(GDM),and to study their associated with the glucose and lipid metabolism indexes levels and the adverse pregnancy outcomes of these women.Methods:72pregnant women with GDM were selected in study group,and 50healthy pregnant women were selected in control group from January 2021to January 2022.The expression levels of serum NRG4,HGF,and SAA,and the levels of glucose and lipid metabolism indexes,such as fasting blood glucose(FPG),postprandial 1hblood glucose(1hPG),postprandial 2hblood glucose(2hPG),total cholesterol(TC),triglyceride(TG),apolipoprotein A(ApoA),high density lipoprotein(HDL),and low density lipoprotein(LDL),of the women in the two groups were detected.The pregnancy outcomes of the women in the two groups were evaluated.According to the pregnancy outcomes of the women,the women in the study group were divided into group A(women with adverse pregnancy outcomes)and group B(women with normal pregnancy outcomes).Pearson correlation analysis was used for the correlation analysis.Results:The levels of NRG4,HGF,and HDL of the women in the study group were significantly lower than those of the women in the control group,while the levels of SAA,TG,TC,LDL,apoA,FPG,1hPG,2hPG,and FINS,and the HOMA-IR value of the women in the study group were significantly higher than those of the women in the control group.Pearson correlation analysis showed that the levels of serum NRG4,HGF,SAA,TG,LDL,HDL,apoA,FPG,2HPG,and FINS,and the HOMA-IR of the women with GDM were correlated each other(all P<0.05).The incidence of adverse pregnancy outcomes(61.1%)of the women in the study group was significantly higher than that(8.0%)of the women in the control group.The serum NRG4and HGF levels of the women in group B were significantly higher than those of the women in group A,and the SAA level of the women in group B was significantly lower than that of the wo

关 键 词：妊娠期糖尿病 神经调节蛋白 肝细胞生长因子 淀粉样蛋白A 糖脂代谢 不良妊娠结局 相关性 

分 类 号：R714.256[医药卫生—妇产科学]