不同性别和年龄人群动脉僵硬度及其相关因素的研究  

erial stiffness and its related factors in different gender and

作　　者：陈建雄 罗向红[3] 谢予晨 沈崔琴 陈晴晴 杜联芳[5] 李朝军 Chen Jianziong;Luo Xianghong;Xie Yuchen;Shen Cuiqin;Chen Qingqing;Du Lianfang;Li Zhaojun(Shanghai General Hospital of Nanjing Medical University,Shanghai 200080,China;Department of Ultrasound,Mindong Hospital Affiliated to Fujian Medical University,Ningde 355000,China;Department of Echocardiography,Shanghai General Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200080,China;Department of Ultrasound,Shanghai General Hospital Jiading Branch,Shanghai Jiaotong University School of Medicine,Shanghai 201803,China;Department of Ultrasound,Shanghai General Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200080,China)

机构地区：[1]南京医科大学附属上海一院临床医学院,上海200080 [2]福建医科大学附属闽东医院超声科,宁德市355000 [3]上海交通大学附属第一人民医院心超室,上海200080 [4]上海交通大学附属第一人民医院嘉定分院超声科,上海201803 [5]上海交通大学附属第一人民医院超声科,上海200080

出　　处：《中华老年医学杂志》2023年第6期664-669,共6页Chinese Journal of Geriatrics

基　　金：上海市自然科学基金(21ZR1451400);上海市科学技术委员会医学引导类科技项目(16411969300);上海市松江区科技攻关项目(18sjkjgg53)。

摘　　要：目的探讨血管僵硬度指标动脉波速指数(AVI)在不同年龄、性别间的差异及其影响因素。方法横断面研究,选取2020年8月至2021年9月在上海市第一人民医院嘉定分院体检者4311例,年龄(57.8±12.8)岁。依据年龄分组为青年组(<45岁)755例、中年组(45~59岁)1260例和老年组(≥60岁)2296例。采用袖带振荡波获取受试者的AVI。AVI≥33定义为高AVI,提示动脉硬化,其中高AVI组122例和正常AVI组4189例。结果青年组、中年组和老年组AVI分别为(12.8±3.7)、(17.5±5.7)、(19.8±6.5),随增龄AVI呈增加(F_(趋势)=767.819,P<0.01)。中年女性高AVI的发生率为2.8%(20/722),高于同年龄组男性的0.9%(5/538),差异有统计学意义(χ^(2)=5.371,P<0.05)。多因素Logistic回归分析结果显示,超重、高身高和脉搏>80次/min是高AVI发生率的保护因素[OR(95%CI):0.468(0.317~0.690)、0.926(0.895~0.958)、0.143(1.026~2.432),均P<0.01];老年、收缩压≥140mmHg(1mmHg=0.133kPa)和舒张压≥90mmHg是其危险因素[OR(95%CI):2.119(1.322~3.396)、6.652(4.136~10.699)、1.580(1.026~2.432),均P<0.05]。结论AVI随增龄而增加,中年女性受试者高AVI的发生率高于男性。年龄、血压增高等因素是发生高AVI的独立危险因素,同时超重和身高因素可能影响AVI测值。Objective To investigate gender differences in arterial velocity pulse index(AVI),which is an indicator of vascular stiffness,across various age groups.Additionally,the study will also examine the risk factors associated with AVI.Methods This cross-sectional study enrolled 4311 patients with an average age of 57.8±12.8 years at Jiading Branch of Shanghai First People's Hospital between August 2020 and September 2021.Patients were divided into three groups based on age:young(<45 years old,n=755),middle-aged(45-59 years old,n=1260),and elderly(≥60 years old,n=2296).The AVI of the subject was obtained using the cuff oscillation wave method.The subject's AVI was acquired using the cuff oscillation wave.High AVI,indicating arteriosclerosis,was defined as AVI≥33.The subjects were then divided into two groups:the high AVI group(122 cases)and the normal AVI group(4189 cases).Results The ankle-brachial index(AVI)was found to be 12.8±3.7,17.5±5.7,and 19.8±6.5 in the young,middle-aged,and elderly groups,respectively.The study revealed that AVI increased with age(F_(rend)=767.819,P<0.01).Additionally,the incidence of high AVI in middle-aged women was found to be(2.8% or 20/722),which was higher than that in men 0.9%(5/538)in the same age group.This difference was statistically significant(χ^(2)=5.371,P<0.05).The results of the multivariate logistic regression analysis indicate that being overweight,having a higher height,and a pulse rate greater than 80 BPM are protective factors in preventing a high incidence of AVI.The odds ratios(OR)with 95% confidence intervals(CI)for these factors were 0.468(0.317-0.690),0.926(0.895-0.958),and 0.143(1.026-2.432),respectively,all with a P-value less than 0.01.On the other hand,old age,systolic blood pressure of 140 mmHg or higher,and diastolic blood pressure of 90 mmHg or higher were identified as risk factors for AVI.The ORs with 95% CIs for these factors were 2.119(1.322-3.396),6.652(4.136-10.699),and 1.580(1.026-2.432),respectively,all with a P-value less than O.05l.Conclusio

关 键 词：动脉波速指数 动脉僵硬度 年龄 性别 

分 类 号：R543.5[医药卫生—心血管疾病]