不同益生菌辅助治疗幽门螺杆菌感染疗效比较  

Comparison of Efficacy of Different Probiotics in the Treatment of Children with Helicobacter Pylori Infection

作　　者：韦依伶 韦丹丽 金伶[1] Wei Yiling;Wei Danli;Jin Ling(People’s Hospital of Liuzhou,Guangxi Liuzhou 545000,China)

机构地区：[1]柳州市人民医院,广西柳州545000

出　　处：《儿科药学杂志》2023年第6期46-49,共4页Journal of Pediatric Pharmacy

摘　　要：目的:优选儿童幽门螺杆菌(Hp)感染的益生菌辅助治疗方案。方法:选取我院2020年8月至2022年8月收治的Hp感染患儿120例,按随机数表法分为试验组1、试验组2、试验组3和对照组各30例。四组患儿均采用常规三联疗法:口服克拉霉素(15 mg/kg,bid)+奥美拉唑肠溶胶囊(0.6~0.8 mg/kg,清晨顿服)+阿莫西林胶囊(25 mg/kg,大剂量1 g,bid);另外,试验组1加用复合乳酸菌胶囊(1粒,tid),试验组2加用双歧杆菌三联活菌胶囊(1粒,tid),试验组3加用布拉酵母菌散(1袋,bid)。三联疗法治疗14 d,益生菌连续治疗1个月。比较四组患儿临床疗效、炎性因子水平、胃蛋白酶水平、临床症状评分及不良反应发生情况。结果:治疗1个月后,四组患儿白细胞介素(IL)-6、肿瘤坏死因子(TNF)-α、超敏C反应蛋白(hs-CRP)、胃蛋白酶原Ⅰ(PGⅠ)及临床症状评分均降低,且试验组(尤其试验组2)低于对照组(P均<0.05);胃蛋白酶原Ⅱ(PGⅡ)和胃蛋白酶原比值(PGR)均升高,且试验组(尤其试验组2)高于对照组(P均<0.05)。试验组(尤其试验组2)总有效率高于对照组(P<0.05)。四组患儿不良发生率为6.67%~13.33%,差异无统计学意义(P>0.05)。结论:采用双歧杆菌三联活菌辅助三联疗法治疗儿童Hp感染临床效果显著,可有效减轻炎性反应,调节胃蛋白酶平衡。Objective:To optimize the adjuvant therapy of probiotics in the treatment of Helicobacter pylori(Hp)infection in children.Methods:A total of 120 children with Hp infection admitted into the hospital from Aug.2020 to Aug.2022 were extracted to be divided into the control group,experimental group 1,experimental group 2,and experimental group 3,with 30 cases in each group.All groups received conventional triple therapy:oral clarithromycin(15 mg/kg,bid)+omeprazole enteric-dissolved capsules(from 0.6 to 0.8 mg/kg,morning meal)+amoxicillin capsules(25 mg/kg,maximum dose 1 g,bid).Meanwhile,experimental group 1 was given compound Lactobacillus capsules(1 capsule,tid)based on conventional triple therapy,experimental group 2 was given Bifidobacterium triple viable bacteria capsules(1 capsule,tid),and experimental group 3 was given Saccharomyces boulardii sachets(1 bag,bid).All patients were treated with triple therapy for 14 d and probiotics for 1 month.The clinical efficacy,levels of inflammatory factors,pepsin levels,clinical symptom scores and incidence of adverse drug reactions among 4 groups were compared.Results:After 1 month of treatment,the levels of interleukin(IL)-6,tumor-necrosis factor(TNF)-α,hypersensitive C-reactive protein(hs-CRP),pepsinogenⅠ(PGⅠ)and clinical symptoms scores in 4 groups decreased significantly,and the experimental groups(especially the experimental group 2)were lower than those of the control group(P<0.05);the levels of pepsinogenⅡ(PGⅡ)and pepsinogen ratio(PGR)in 4 groups increased significantly compared with those before treatment,and the experimental groups(especially the experimental group 2)were higher than those of the control group(P<0.05).The total effective rates of experimental groups(especially experimental group 2)was higher than those of the control group(P<0.05).The total incidence of adverse drug reactions in experimental groups was from 6.67%to 13.33%,without significant difference(P>0.05).Conclusion:The clinical effects of Bifidobacterium triple viable bacteria combi

关 键 词：益生菌 幽门螺杆菌 三联疗法 双歧杆菌三联活菌 

分 类 号：R725.7[医药卫生—儿科]