Advanced maternal age and adverse obstetrical and neonatal outcomes of singleton pregnancies  

作　　者：Mitra Shekari Malihe Shirzadfardjahromi Amene Ranjbar Vahid Mehrnoush Fatemeh Darsareh Nasibeh Roozbeh 

机构地区：[1]Mother and Child Welfare Research Center,Hormozgan University of Medical Sciences,Bandar Abbas,Iran [2]Fertility and Infertility Research Center,Hormozgan University of Medical Sciences,Bandar Abbas,Iran [3]Urology Department,Northern Ontario School of Medicine,Thunder Bay,Ontario,Canada

出　　处：《Gynecology and Obstetrics Clinical Medicine》2022年第4期175-180,共6页妇产科临床医学（英文）

基　　金：This study complies with the Declaration of Helsinki and was performed according to ethics committee approval.The Ethics and Research Committee of the Hormozgan University of Medical Sciences approved the study(number:HUMS.REC.1401.115).

摘　　要：Objective:To assess the impact of advanced maternal age on pregnancy and childbirth outcomes of singleton pregnancies.Study design:We retrospectively assessed singleton pregnant mothers who gave birth at Khaleej-e-Fars Hospital in Bandar Abbas,Iran,from January 2020 to January 2022.Demographic and obstetrical factors include educational level,medical insurance,residency place,access to prenatal care facilities,number of prenatal care visits,smoking status,gestational age,parity,infertility,maternal comorbidities,preeclampsia,eclampsia,preterm birth,low birth weight(LBW),intrauterine growth restriction(IUGR),macrosomia,placenta abnormalities(previa/acreta),placenta abruption,chorioamnionitis,meconium fluid,fetal distress,methods of delivery,rate of cesarean section(CS),perineal lacerations,postpartum hemorrhage,childbirth injury,shoulder dystocia,congenital malformation,neonatal asphyxia,and unfavorable maternal and neonatal outcome were compared between two groups.The Chi-square test assessed the relationship between categorical factors and maternal age groups.The influence of advanced maternal age on the risk of unfavorable pregnancy outcomes was evaluated using bivariate and multivariate logistic regression.Results:Of 8354 singleton deliveries,22.2%belonged to advanced-age mothers.Advanced-age mothers had less education than those aged 20–34 years old.Chronic hypertension,cardiovascular disease,overt diabetes,and thyroid dysfunction were more prevalent among advanced-age mothers.Compared with mothers aged 20–34 years,mothers aged 35 years and higher had a significantly higher risk of gestational diabetes(aOR:3.18,95%CI:1.56–6.95),preeclampsia(aOR:2.91,95%CI:1.35–4.72),placenta abnormalities(aOR:1.09,95%CI:0.77–1.94),CS(aOR:3.16,95%CI:1.51–3.87),postpartum hemorrhage(aOR:1.94,95%CI:1.24–2.61),intensive care unit admission(aOR:1.36,95%CI:1.15–1.99),LBW(aOR:1.35,95%CI:0.97–2.96),preterm birth(aOR:2.36,95%CI:1.65–4.83),stillbirth(aOR:1.18,95%CI:1.01–3.16),and neonatal intensive care admission(

关 键 词：Advanced maternal age PREGNANCY CHILDBIRTH Perinatal outcome Neonatal outcomes 

分 类 号：R714.2[医药卫生—妇产科学]