Association of anti-mullerian hormone and free androgen index level on response to clomiphene citrate in PCOS infertile women  

作　　者：Jasmine Kavitha Washington Jayasree Manivasakan Poomalar Gunasekaran Kala Sasikala R. 

机构地区：[1]Department of OBGyn,Sree Balaji Medical College and Hospital,Chennai,India [2]Department of OBGyn,Sri Manakula Vinayagar Medical College and Hospital,Pondicherry,India [3]Department of OBGyn,Aarupadai Veedu Medical College and Hospital,Pondicherry,India

出　　处：《Gynecology and Obstetrics Clinical Medicine》2022年第4期203-207,共5页妇产科临床医学（英文）

摘　　要：Background:Polycystic ovary syndrome(PCOS)is the leading cause of anovulatory infertility.Clomiphene citrate,insulin-sensitizing drugs,aromatase inhibitors,gonadotropins,or laparoscopic ovarian drilling are various methods used for ovulation induction in women with PCOS.PCOS women with high levels of anti-mullerian hormone(AMH)and free androgen index(FAI)do not respond well to ovulation induction.This prospective observational study explores the relationship between FAI and AMH levels on ovarian response to clomiphene citrate in infertile women with PCOS.Methods:This prospective observational study included 40 infertile with PCOS who underwent ovulation induction with clomiphene citrate with dose ranging from 50 to 150 mg.Participants were classified into four phenotypes by NIH(National Institute of Health)consensus panel criteria.The clinical and endocrine parameters of participants who were sensitive to clomiphene were compared to those who were resistant.Results:The most common phenotype was A,with all three features of PCOS:hyperandrogenism,ovulatory dysfunction,and polycystic ovarian morphology.There was no significant difference in clinical and endocrine parameters among the different phenotypes of PCOS except AMH and FAI values.The mean FAI was 9.391.11 and AMH 7.260.48(ng/ml)in clomiphene resistant and 5.311.93 and 3.691.84(ng/ml)respectively in clomiphene-sensitive women.Women with FAI>7.5 and AMH>7 ng/ml might be resistant to clomiphene.Conclusion:FAI and AMH values were significantly higher in women resistant to clomiphene induction.AMH and FAI may help women with PCOS to tailor their ovulation induction protocol.

关 键 词：Free androgen index anti-Mullerian hormone CLOMIPHENE INFERTILITY Polycystic ovarian syndrome 

分 类 号：R711.75[医药卫生—妇产科学] R711.6[医药卫生—临床医学]