CLN3 clinches lysosomes in clearance of glycerophospholipids  

作　　者：Guang Lu Han-Ming Shen 

机构地区：[1]Department of Physiology,Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou,Guangdong 510080,China [2]Department of Biomedical Sciences,Faculty of Health Sciences,Ministry of Education Frontiers Science Center for Precision Oncology,University of Macao,Macao 999078,China

出　　处：《Life Metabolism》2023年第1期6-7,共2页生命（代谢（英文）

摘　　要：CLN3 is a lysosomal transmembrane protein and loss of CLN3 is known to cause a juvenile lethal neurodegenerative lysosomal storage disorder(LSD),called Batten disease.In a recent study published in Nature,Laqtom et al.reported a novel function of CLN3 in the clearance of glycerophospholipid from lysosomes via lysosomal efflux of glycerophosphodiesters(GPDs),not only establishing a deeper mechanistic understanding of Batten disease,but also suggesting both the diagnostic and therapeutic potential of CLN3-GPDs in this type of neurodegenerative LSD.

关 键 词：CLN3 PHOSPHOLIPIDS establishing 

分 类 号：Q251[生物学—细胞生物学]