Cor、FT3评价HBV感染相关慢加急性肝衰竭患者病情进展的应用价值  

Application value of Cor and FT3 in evaluating the progression of HBV infection related to chronic and acute liver failure patients

作　　者：朱江 董海英[2] 张英[1] ZHU Jiang;DONG Haiying;ZHANG Ying(Department of Gastroenterology,the Second Hospital of Qinhuangdao City,Hebei Province,Qinhuangd-ao,Hebei,China,066600;Department of Health Care,the Second Hospital of Qinhuangdao City,Hebei Province,Qinhuangdao,Hebei,China,066600)

机构地区：[1]河北省秦皇岛市第二医院消化科,河北秦皇岛066600 [2]河北省秦皇岛市第二医院保健科,河北秦皇岛066600

出　　处：《分子诊断与治疗杂志》2023年第5期838-841,共4页Journal of Molecular Diagnostics and Therapy

基　　金：秦皇岛市科学技术研究与发展计划项目(201902A150)。

摘　　要：目的分析Cor、FT3评价HBV感染相关慢加急性肝衰竭患者病情进展的应用价值。方法选取2019年1月到2021年12月秦皇岛市第二医院收治的82例HBV感染相关慢加急性乙型肝炎肝衰竭患者,按照病历资料中患者入院时病情程度将患者分为早期组、中期组和晚期组,对比不同病情程度患者的Cor、FT3水平的差异,分析Cor、FT3水平与HBV感染相关慢加急性肝衰竭病情进展的相关性。并根据病历资料中病情转归情况将患者分为预后良好组和预后不良组,对比两组患者的Cor、FT3水平,并绘制ROC曲线分析Cor、FT3水平对患者预后的预测价值。结果各组Cor、FT3水平比较为:早期组>中期组>晚期组,差异具有统计学意义(F=13.769、9.940;P<0.05)。Cor、FT3水平与HBV感染相关慢加急性肝衰竭的病情进展呈正相关关系(r=-0.516、-0.438,P均<0.05)。预后良好组患者的Cor、FT3水平明显高于预后不良组,差异具有统计学意义(t=6.200、3.336;P<0.05)。ROC曲线分析结果显示,Cor、FT3单独预测曲线下面积分别为0.843,0.669,联合预测的曲线下面积为0.849。结论Cor、FT3评价HBV感染相关慢加急性肝衰竭病情进展的具有一定的相关关系,同时对患者的预后具有一定的预测价值,可为HBV感染相关慢加急性肝衰竭病情及预后的评估提供参考。Objective To analyze the application value of Cor and FT3 in evaluating the progres⁃sion of chronic and acute liver failure related to HBV infection.Methods From January 2019 to December 2021,82 patients with HBV infection⁃related chronic and acute hepatitis B liver failure were selected retrospec⁃tively.According to the degree of illness in the medical records,the patients were divided into the early group,the middle⁃term group and the late group.The differences of Cor and FT3 levels in patients with different de⁃grees of illness were compared,and the correlation between the levels of Cor and FT3 and the progression of HBV infection related chronic and acute liver failure was analyzed.The patients were divided into the good prognosis group and the poor prognosis group according to the prognosis in medical records.The levels of Cor and FT3 in the two groups were compared,and the ROC curve was drawn to analyze the predictive value of Cor and FT3 levels on the prognosis of patients.Results The levels of Cor and FT3 in each group were as fol⁃lows:early group>middle⁃term group>late group,with statistical significance(F=13.769,9.940;P<0.05)The levels of Cor and FT3 were positively correlated with the progression of chronic and acute liver failure re⁃lated to HBV infection(r=-0.516,-0.438,P<0.05).The levels of Cor and FT3 in patients with good progno⁃sis were significantly higher than those in patients with poor prognosis(t=6.200,3.336;P<0.05).The ROC curve analysis shows that the area under the curve predicted by Cor and FT3 alone is 0.843 and 0.669 respec⁃tively,while the area under the curve predicted by the joint prediction is 0.849.Conclusion The evaluation of the progression of HBV infection related chronic and acute liver failure by Cor and FT3 has a certain correla⁃tion and has a certain predictive value for the prognosis of patients.It can provide reference for the evaluation of the condition and prognosis of HBV infection related chronic and acute liver failure.

关 键 词：血清皮质醇 血清游离三甲碘状腺原氨酸 HBV感染相关慢加急性肝衰竭 病情进展 

分 类 号：R512.62[医药卫生—内科学] R575.3[医药卫生—临床医学]