CysC、SAA及IgM在川崎病患儿冠状动脉损伤中的预测价值  

The value of CysC,SAA and IgM in the prediction of coronary artery injury in children with Kawasaki disease

作　　者：金敏欣 孙胜涛[2] 潘筱[2] JIN Minxin;SUN Shengtao;PAN Xiao(Clinical Medical College,Weifang Medical College,Weifang,Shandong,China,261000;Department of Pediatrics,the Second Ward,Linyi People's Hospital,Linyi,Shandong,China,276000)

机构地区：[1]潍坊医学院临床医学院,山东潍坊261000 [2]临沂市人民医院儿内科二病区,山东临沂276000

出　　处：《分子诊断与治疗杂志》2023年第5期884-887,共4页Journal of Molecular Diagnostics and Therapy

基　　金：山东省自然科学基金项目(ZR2020HL21)。

摘　　要：目的分析胱抑素(CysC)、血清淀粉样蛋白A(SAA)及免疫球蛋白M(IgM)在川崎病(KD)患儿冠状动脉损伤(CAL)中的预测价值。方法选取2021年1月至2022年9月临沂市人民医院收治的120例KD患儿作为研究对象,根据超声结果分为观察组(发生CAL,n=60)与对照组(未发生CAL,n=60),比较两组CysC、SAA及IgM水平,采用Logistic多因素分析影响KD患儿发生CAL的因素,分析CysC、SAA及IgM水平对KD患儿发生CAL的预测价值。结果观察组患儿CysC、SAA及IgM水平均高于对照组,差异有统计学意义(P<0.05)。Logistic多因素分析结果显示,年龄<3岁、治疗前发热时间>6 d、非典型KD及血清CysC、SAA、IgM、WBC是影响KD患儿发生CAL的危险因素(P<0.05)。ROC结果显示,三者联合(CysC+SAA+IgM)预测AUC值为0.823(95%CI:0.744~0.901),高于各指标单独预测。结论CysC、SAA及IgM水平在KD并发CAL患儿中呈异常高表达,且CysC、SAA及IgM是KD患儿诱发CAL的相关危险因素,联合检测上述三项指标可提高对CAL的预测效果。Objective To analyze the effects of CysC,SAA and IgM in the prediction of coronary artery injury(CAL)in children with Kawasaki disease(KD).Methods 120 children with KD admitted to our hospital from January 2021 to September 2022 were selected as the research objects.According to the ultrasound results,they were divided into the observation group(CAL occurs,n=60)and the control group(No CAL occurred,n=60).The levels of CysC,SAA and IgM were compared between the two groups.The data of the patients were collected,and the factors affecting the occurrence of CAL in children with KD were analyzed by Logistic multivariate analysis,and the receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of CysC,SAA and IgM levels on the occurrence of CAL in children with KD.Results The levels of CysC,SAA and IgM in the observation group were higher than those in the control group(P<0.05).Logistic multivariate analysis showed that age<3 years old,fever time>6 days before treatment,atypical KD and serum CysC,SAA,IgM,WBC were the risk factors affecting the occurrence of CAL in children with KD(P<0.05).The ROC results show that the AUC value predicted by the combination of the three(CysC+SAA+IgM)is 0.823(95%CI:0.744~0.901),which is higher than that of predicted by each indicator alone.Conclusion The levels of CysC,SAA and IgM were abnormally high in children with KD complicated with CAL,and CysC,SAA and IgM were related risk factors for inducing CAL in children with KD.The combined detection of the above three indicators can improve the prediction effect on CAL.

关 键 词：川崎病 冠状动脉损伤 胱抑素 血清淀粉样蛋白A 免疫球蛋白M 

分 类 号：R725.4[医药卫生—儿科]