冠状动脉粥样硬化性心脏病临证处方活血化瘀药运用规律分析  

Analysis of the application patterns of blood-activating and stasis-removing drugs in empirical prescriptions for coronary artery atherosclerotic heart disease

作　　者：赵珈瑶 李倩 于明江·木拉提 赵建华 Zhao Jia-yao;Li Qian;Yu Ming-jiang·Mulati;Zhao Jian-hua(Beijing University of Chinese Medicine,Beijing 100105,China;Urumqi Traditional Chinese Medicine Hospital,Urumqi 830099,China;Urumqi Maternal and Child Health Care Hospital,Urumqi 830001,China)

机构地区：[1]北京中医药大学,北京100105 [2]乌鲁木齐市中医医院,新疆乌鲁木齐830099 [3]乌鲁木齐市妇幼保健医院,新疆乌鲁木齐830001

出　　处：《四川生理科学杂志》2023年第6期952-955,959,共5页Sichuan Journal of Physiological Sciences

基　　金：国家自然科学基金(No.30660219)。

摘　　要：目的:应用方剂计量学方法探讨现代医家对冠心病医治过程中活血化瘀药物的运用规律。方法:对现代医家医治冠心病的临证处方中的活血化瘀药使用方剂计量学方法进行频数、构成比和同用度分析。探讨医治冠心病的高频活血化瘀药及临证处方中活血化瘀药的应用规律。结果:高频活血化瘀药依次为丹参,桃仁,红花,当归,川芎。含有2味活血化瘀药的处方最多,占比高达18.01%。平均每方含2.36味活血化瘀药。活血化瘀药的性味以苦、温、辛、甘为主,归经以肝经、心经、心包经为主。主要症状依次为胸闷,胸痛,心悸,怔仲、短气、气喘、胸痞、呕吐、头晕、恶心。桃仁,红花,当归,赤芍同用度指数高,其中以桃仁、红花同用度指数最大。丹参、姜黄的同用度指数最小。冠心病急性期活血化瘀药多以破血消徵为主,如三棱,莪术,土鳖虫。缓解期活血化瘀药以活血通络,养血和血为主,如当归,川芎,丹参。结论:本文运用方剂计量学方法对众多医家医治冠心病进行经验提取,剖析活血化瘀药的应用规律,为该病辨证、分期、用药提供科学依据。Objective:This study aims to explore the application patterns of blood-activating and stasis-removing drugs in the treatment of coronary artery atherosclerotic heart disease by modern physicians using the method of formula-based pharmacometrics.Methods:Formula-based pharmacometrics was used to analyze the frequency,composition ratio,and co-prescription of blood-activating and stasis-removing drugs in the empirical prescriptions of modern physicians for the treatment of coronary artery atherosclerotic heart disease.The study investigates the high-frequency blood-activating and stasis-removing drugs used in the treatment of coronary artery atherosclerotic heart disease and their application patterns in empirical prescriptions.Results:The high-frequency blood-activating and stasis-removing drugs were Danshen,Taoren,Honghua,Danggui,and Chuanxiong,in descending order.Prescriptions containing two blood-activating and stasis-removing drugs were the most common,accounting for 18.01%.On average,each prescription contained 2.36 blood-activating and stasis-removing drugs.The taste and nature of blood-activating and stasis-removing drugs were predominantly bitter,warm,spicy,and sweet,while the meridians they targeted were mainly the Liver meridian,Heart meridian,and Pericardium meridian.The main symptoms treated were chest tightness,chest pain,palpitations,dizziness,shortness of breath,wheezing,chest discomfort,vomiting,dizziness,and nausea.Taoren,Honghua,Danggui,and Chishao had high co-prescription indexes,with Taoren and Honghua having the highest index.Danshen and Jianghuang had the lowest co-prescription indexes.During the acute phase of coronary artery atherosclerotic heart disease,blood-activating and stasis-removing drugs were mainly used to break up blood stasis and alleviate symptoms,such as Sanleng,Ezhu,and Tubiechong.During the relief phase,blood-activating and stasis-removing drugs were mainly used to promote blood circulation,nourish blood,and invigorate blood,such as Danggui,Chuanxiong,and Danshen.Conclusion:Th

关 键 词：冠状动脉粥样硬化性心脏病 活血化瘀药 用药规律 

分 类 号：R541.4[医药卫生—心血管疾病]