熊果酸抗纤维化研究进展  

Research Progress of Ursolic Acid Anti-fibrosis

作　　者：侯梦珠 李春玉[1,2] 王丽敏[1,2] 赵冬梅[1,2] 刘洁薇[1,2] Hou Mengzhu;Li Chunyu;Wang Limin;Zhao Dongmei;Liu Jiewei(Jiamusi University,Jiamusi 154007;First Affiliated Hospital of Jiamusi University,Jiamusi 154003,China)

机构地区：[1]佳木斯大学临床医学院,黑龙江佳木斯154007 [2]佳木斯大学附属第一医院儿科学,黑龙江佳木斯154003

出　　处：《广东化工》2023年第12期101-102,117,共3页Guangdong Chemical Industry

基　　金：黑龙江省卫生健康委科研课题(2020-331);佳木斯大学青年创新人才培养计划(JMSUQP2020018)。

摘　　要：最近越来越多有关熊果酸的研究表明熊果酸具有抗脏器纤维化的作用,但是其抗纤维化的作用机制仍需进一步探究。熊果酸有镇静、抗炎、抗氧化、抗菌、抗糖尿病、抗溃疡、抗纤维化和恢复肝功能的作用。此外,熊果酸还被广泛用于药品和化妆品中,是因为其具有显著的抗氧化特性。本文对熊果酸在治疗中的研究结果进行整合,阐述了熊果酸的抗纤维化作用机制及其效果,并对熊果酸在临床实践中的进一步应用提出了建议。Recently,more and more studies on ursolic acid have shown that ursolic acid has anti-fibrosis effect,but its anti-fibrosis mechanism still needs further exploration.Ursolic acid has sedative,anti-inflammatory,anti-oxidant,anti-bacterial,anti-diabetic,anti-ulcer,anti-fibrosis and recovery of liver function.In addition,ursolic acid is also widely used in pharmaceuticals and cosmetics because of its significant antioxidant properties.In this paper,the research results of ursolic acid in the treatment are integrated,the anti-fibrosis mechanism and effect of ursolic acid are expounded,and the further application of ursolic acid in clinical practice is proposed.

关 键 词：熊果酸 工艺制备 心肌纤维化 肝纤维化 肾间质纤维化 肺纤维化 

分 类 号：TQ[化学工程]