制剂新技术与新剂型提高二氢杨梅素生物利用度的研究进展  

Research progress on improving bioavailability of dihydromyricetin by using new preparation technology and new dosage form

作　　者：田茂仙 李娟[1] 施春阳 方建国[1,2] 王文清[1] 汪秋兰 尹明星 TIAN Mao-xian;LI Juan;SHI Chun-yang;FANG Jian-guo;WANG Wen-qing;WANG Qiu-lan;YIN Ming-xing(Department of Pharmacy,Tongji Hospital Affiliated with Tongji Medical College,Huazhong University of Science and Technology,Hubei Wuhan 430030,China;Tongji-Rongcheng Center for Biomedicine,Huazhong University of Science and Technology,Hubei Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院药学部,湖北武汉430030 [2]华中科技大学同济-荣程生命科学与医学研究中心,湖北武汉430030

出　　处：《中国医院药学杂志》2023年第10期1160-1164,1178,共6页Chinese Journal of Hospital Pharmacy

基　　金：国家自然科学基金青年科学基金项目(编号:81503013);湖北省自然科学基金项目(编号:2017CFB481)。

摘　　要：二氢杨梅素是藤茶的主要药效物质,具有多种显著的药理活性,但低生物利用度制约了其临床应用。近年来,各种制剂技术为改善二氢杨梅素溶解度及提高其生物利用度提供了新途径,为其成药性提供了有效的解决办法。该文综述了二氢杨梅素各种制剂技术与剂型提高其生物利用度的研究进展,分析新剂型在改善二氢杨梅素成药性发展中面临的问题,以期为其开发和应用提供参考。Dihydromyricetin is the main medicinal substance of vine tea,which has many significant pharmacological activities,but its low bioavailability restricts its clinical application.In recent years,various preparation technologies have provided new ways to improve the solubility and bioavailability of dihydromyricetin,providing an effective solution for its drug formation.This paper reviewed the research progress of various preparation technologies and dosage forms of dihydromyricetin to improve its bioavailability,and analyzed the problems faced by new dosage forms in improving the development of druggability of dihydromyricetin,in order to provide reference for the development and application of dihydromyricetin.

关 键 词：二氢杨梅素 制剂新技术 新剂型 生物利用度 

分 类 号：R945[医药卫生—微生物与生化药学]