星点设计-响应面法优化广藿香挥发油β-环糊精包合物的高速剪切包合工艺  

Optimization of high speed shear inclusion process of Pogostemon cablin volatile oilβ-cyclodextrin inclusion by central composite design and response surface method

作　　者：余欣彤 黄森 邓桂海 徐东婷 邱彩月 张雪兰 刘燎原 YU Xin-tong;HUANG Sen;DENG Gui-hai;XU Dong-ting;QIU Cai-yue;ZHANG Xue-lan;LIU Liao-yuan(Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Formula Granule,Guangdong Yi Fang Pharmaceutical Co.,Ltd,Foshan 528244,China)

机构地区：[1]广东一方制药有限公司广东省中药配方颗粒企业重点实验室,广东佛山528244

出　　处：《现代药物与临床》2023年第5期1088-1093,共6页Drugs & Clinic

基　　金：佛山应急科技攻关专项(2020001000206);佛山市科技创新项目(2120001002309)。

摘　　要：目的优选广藿香挥发油β-环糊精包合物制备的高速剪切包合工艺。方法在单因素考察的基础上,以收得率、包合率的综合评分为评价指标,采用G1-熵权法结合星点设计-响应面法,对剪切转速、剪切时间、β-环糊精与挥发油质量比例进行考察。通过Design-Expert 8.0.6.1软件分析各因素的交互作用优选最佳工艺参数。结果采用高速剪切法制备广藿香挥发油β-环糊精包合物的最佳包合工艺条件为:β-环糊精与挥发油质量比例8∶1,剪切时间3 min,剪切转速4200 r/min,β-环糊精与水质量比例1∶7。结论优化了广藿香挥发油β-环糊精包合物的高速剪切法制备的最佳工艺参数,为后续相关产品的开发研究和生产提供指导。Objective To optimize the preparation process of Pogostemon cablin volatile oilβ-cyclodextrin inclusion.Methods On the basis of single factor investigation,G1-entropy weight method combined with central composite design and response surface method was used.Shear speed,shear time,and the ratio ofβ-cyclodextrin to volatile oil were investigated with the comprehensive score of yield rate and inclusion rate as evaluation indexes.The interaction of various factors was analyzed by Design-Expert 8.0.6.1 software,and the optimized preparation process was investigated.Results The optimal inclusion process of high speed shear inclusion process was as follows:the ratio ofβ-cyclodextrin to volatile oil was 8∶1,the shear time was 3 min,the shear speed was 4200 r/min,and the ratio ofβ-cyclodextrin to water was 1∶7.Conclusion The optimized inclusion process of Pogostemon cablin volatile oilβ-cyclodextrin inclusion is optimized,and can provide guidance for the development and production of related products in the future.

关 键 词：广藿香挥发油 β-环糊精 包合物 高速剪切 收得率 包合率 星点设计-响应面法 

分 类 号：R284.2[医药卫生—中药学]