姜黄素防治急性胰腺炎的作用机制研究进展  

Research progress on mechanism of curcumin in prevention and treatment of acute pancreatitis

作　　者：赵利灿 聂雨 徐禹[1] 杜爱平[1] 徐宇军 田永明[1] ZHAO Li-can;NIE Yu;XU Yu;DU Ai-ping;XU Yu-jun;TIAN Yong-ming(Department of Critical Medicine,West China Hospital of Sichuan University,Chengdu 610044,China;Zunyi Central Blood Station,Zunyi 563000,China)

机构地区：[1]四川大学华西医院重症医学科,四川成都610044 [2]遵义市中心血站,贵州遵义563000

出　　处：《现代药物与临床》2023年第5期1266-1271,共6页Drugs & Clinic

基　　金：四川省科技计划项目(2022JDR0204)。

摘　　要：急性胰腺炎是常见的临床急性腹部疾病,其起病急、进展迅速、结局不良,限制炎症发展是急性胰腺炎治疗的有效策略。姜黄素是一种来自姜黄的黄色素,具有抗纤维化、抗癌、抗细胞凋亡和抗炎等多种活性。姜黄素可通过抑制核因子-κB(NF-κB)相关通路的活性,调控丝裂原活化蛋白激酶(MAPK)信号通路,抑制Janus激酶2(JAK2)/信号转导及转录激活蛋白3(STAT3)信号通路,激活肌醇磷脂-3-激酶(PI3K)/丝氨酸-苏氨酸激酶(Akt)信号通路,抑制炎症因子分泌,抑制趋化因子上皮中性粒细胞激活肽78(ENA-78)的表达,抑制环氧化酶2(COX-2)的表达,改善细胞自噬功能,抑制胰腺星状细胞活化,减轻氧化应激反应,发挥防治急性胰腺炎的作用。综述了姜黄素防治急性胰腺炎的作用机制,以期为姜黄素的临床研究提供参考。Acute pancreatitis is a common acute abdominal disease with acute onset,rapid progression,and poor outcome,and limiting inflammation is an effective strategy for treatment of acute pancreatitis.Curcumin is a yellow pigment derived from Curcumae Longae Rhizoma,which has many activities,such as anti-fibrosis,anti-cancer,anti-apoptosis,and anti-inflammatory.Curcumin can inhibit NF-κB,regulate MAPK signal pathway,inhibit JAK2/STAT3 signaling pathway,activate PI3K/Akt signaling pathway,inhibit the secretion of inflammatory factors,inhibit the expressions of ENA-78 and COX-2,improve the autophagy function of cells,inhibit the activation of pancreatic stellate cells,reduce the oxidative stress reaction,and play a role in prevention and treatment of acute pancreatitis.This article reviews the mechanism of curcumin in prevention and treatment of acute pancreatitis,in order to provide reference for the clinical research of curcumin.

关 键 词：姜黄素 急性胰腺炎 核因子-κB通路 肌醇磷脂-3-激酶/丝氨酸-苏氨酸激酶通路 趋化因子上皮中性粒细胞激活肽78 环氧化酶2 细胞自噬 氧化应激反应 

分 类 号：R966[医药卫生—药理学]