水基胶中多种化合物的同时测定  

Simultaneous determination of multiple compounds in water-based adhesive

作　　者：杨飞[1] 周芸[2] 张玉璞 鞠华波 严俊[2] 孟冬玲[2] 邓惠敏[1] 唐纲岭[1] 陈志燕 Yang Fei;Zhou Yun;Zhang Yupu;Ju Huabo;Yan Jun;Meng Dongling;Deng Huimin;Tang Gangling;Chen Zhiyan(China National Tobacco Quality Supervision&Test Center,Zhengzhou 450001,Henan,China;China Tobacco Guangxi Industrial Co.,Ltd.,Nanning 530001,Guangxi,China;Jilin Tobacco Quality Supervision&Test Station,Changchun 130062,Jilin,China;Northwest Tobacco Quality Supervision&Test Station,Lanzhou 730030,Gansu,China)

机构地区：[1]国家烟草质量监督检验中心,河南郑州450001 [2]广西中烟工业有限责任公司,广西南宁530001 [3]吉林省烟草质量监督检测站,吉林长春130062 [4]西北烟草质量监督检测站,甘肃兰州730030

出　　处：《中国胶粘剂》2023年第5期46-52,58,共8页China Adhesives

摘　　要：建立了同时测定水基胶中异噻唑啉酮类杀菌剂和双酚A、壬基酚、辛基酚和邻苯二甲酸酯类环境激素的方法。样品经甲醇提取后,直接进超高效液相色谱-串联质谱(UPLC-MS/MS)分析,采用同位素内标法定量。研究结果表明:所有化合物在20~500 ng/mL浓度范围内线性关系良好(R^(2)≥0.9983),检出限(LOD)和定量限(LOQ)分别在0.009~0.115 mg/kg和0.029~0.382 mg/kg范围内;不同浓度水平下,所有待测物的回收率在84.1%~105.6%之间,日间相对标准偏差(RSD)小于8.0%;对60个实际样品进行检测,所有样品均检出异噻唑啉酮类杀菌剂,各有1个样品检出壬基酚和邻苯二甲酸二丁酯。本方法检测效率高,节约检测成本,尤其适合实验室大批量样品的日常检测。A method was developed for the simultaneous determination of isothiazolinone fungicides and environmental hormones such as bisphenol A,nonylphenol,octylphenol and phthalate in water-based adhesive.After methanol extraction,the sample was directly analyzed by ultra-high performance liquid chromatographytandem mass spectrometry(UPLC-MS/MS)and quantified by isotope internal standard method.The research results showed that all compounds showed good linearity(R^(2)≥0.9983)within the concentration range of 20~500 ng/mL,and the limit of detection(LOD)and limit of quantification(LOQ)were in the range of 0.009~0.115 mg/kg and0.029~0.382 mg/kg,respectively.At different concentration levels,the recovery rates of all analytes were in the range of 84.1%to 105.6%,the daytime relative standard deviation(RSD)was less than 8.0%.Sixty actual samples were tested,all samples detected isothiazolinone fungicides,and one sample each detected nonylphenol and dibutyl phthalate.This method had high detection efficiency and saved detection costs,especially suitable for routine detection of large batches of samples in the laboratory.

关 键 词：水基胶 超高效液相色谱-串联质谱 双酚A 烷基酚 邻苯二甲酸酯 异噻唑啉酮 

分 类 号：O657.63[理学—分析化学]