某院中成药不良反应的帕累托图分析  

Pareto Chart Analysis of Adverse Reactions of Chinese Patent Medicines in A Hospital

作　　者：李明 LI Ming(Department of Pharmacy,Qingpu Branch of Zhongshan Hospital Afiliated to Fudan University,Shanghai 201700,China)

机构地区：[1]复旦大学附属中山医院青浦分院药剂科,上海201700

出　　处：《中国药物经济学》2023年第5期69-73,77,共6页China Journal of Pharmaceutical Economics

基　　金：上海市临床药学重点专科建设项目(沪卫计药政[2018]9号)。

摘　　要：目的分析中成药的药品不良反应(ADR)规律和特点,促进临床合理使用中成药。方法收集复旦大学附属中山医院青浦分院2008年1月至2020年12月上报至国家药品不良反应监测中心的ADR报告,通过帕累托图来分析发生ADR的患者年龄、累及器官/系统、药品种类以及不合理因素。结果共收集ADR报告401份,帕累托图分析结果显示,50岁以上中老年患者较多(208例,51.87%),主要累及器官/系统以皮肤及附件系统、消化系统(354例,67.82%),品种以理血类中成药(165例,41.15%)为主,不合理因素主要为用法用量不适宜(45例,38.46%)。结论临床用药应全面考虑ADR影响因素和用药合理性,以减少ADR的发生。Objective To analyze the rules and characteristics of adverse drug reactions(ADR)of traditional Chinese patent medicines,and promote the rational use of traditional Chinese patent medicines in clinical practice.Methods We collected ADR reports from Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University from January 2008 to December 2020,and analyzed the age,affected organs/systems,drug types,and unreasonable factors of patients with ADR using Pareto diagrams.Results A total of 401 ADR reports were collected.The Pareto chart analysis showed that there were more middle-aged and elderly patients over 50 years old(208 cases,51.87%).The main organs/systems involved were skin and accessory system and digestive system(354 cases,67.82%),the varieties were mainly blood-regulating Chinese patent medicines(165 cases,41.15%),and the main unreasonable factors were inappropriate usage and dosage(45 cases,38.46%).Conclusion Clinical medication should fully consider the influencing factors of ADR and the rationality of medication to reduce the occurrence of ADR.

关 键 词：中成药 药品不良反应 帕累托图分析 合理用药 

分 类 号：R288[医药卫生—中药学]