血清H.pylori抗体抗Hp细胞毒素相关基因A及13C-尿素呼气实验结果与湖州地区孕妇妊娠剧吐的相关性分析  

Serum H.pylori antibody,CagA and 13C-urea breath test resultsand clinical study of hyperemesis gravidarum in Huzhou

作　　者：钱利强 潘皆慰 俞燮龑 王珑玲 徐忠云 於佳 QIAN Li-qiang;PAN Jie-wei;YU Xie-yan;WANG Ling-long;XU Zhong-yun;YU Jia(Department of Obstetrics and Gynecology,Huzhou Maternity and Child Health Care Hospital,Huzhou,Zhejiang,313000,China)

机构地区：[1]湖州市妇幼保健院妇产科,浙江湖州313000

出　　处：《中国妇幼保健》2023年第12期2266-2269,共4页Maternal and Child Health Care of China

基　　金：浙江省湖州市公益性应用研究项目(2019GYB46)。

摘　　要：目的分析血清H.pylori抗体、抗Hp细胞毒素相关基因A(CagA)及13C-尿素呼气实验结果与湖州地区孕妇妊娠剧吐的相关性。方法选取2019年7月—2020年6月于湖州市妇幼保健院就诊的妊娠剧吐(观察组)与无妊娠呕吐(对照组)的孕妇各100例进行研究,并将观察组按病情严重程度分为重度组与轻度组,入组后检测血清H.pylori抗体、抗Hp细胞毒素相关基因A(CagA)及进行13C-尿素呼气实验,比较各组检测结果、孕前及孕早期体质量、孕妇并发症及围生儿不良妊娠结局。结果观察组孕妇Hp、CagA及13C-尿素呼气阳性率均高于对照组,差异均有统计学意义(χ^(2)=26.299,44.907,28.926,均P<0.05)。将观察组孕妇按病情严重程度分组,重度组孕妇Hp及13C-尿素呼气阳性率均高于轻度组(χ^(2)=4.005,5.654,均P<0.05)。CagA阳性率组间比较差异无统计学意义(χ^(2)=3.287,P>0.05)。孕早期观察组体质量较孕前减轻,对照组较孕前增重,差异有统计学意义(t=0.279,P<0.05)。孕早期观察组体质量较对照组轻,差异有统计学意义(t=3.357,P<0.05)。两组孕妇并发症发生率比较差异无统计学意义(P<0.05)。观察组小于胎龄儿、低出生体质量发生率及不良妊娠结局总发生率高于对照组(P<0.05)。结论Hp感染与妊娠剧吐密切相关,妊娠剧吐可导致孕妇体质量减轻、不良妊娠结局发生率增高。Objective To analyze the correlation of serum H.pylori antibody,anti-Hp cytotoxin related gene A(CagA)and 13C-u-rea breath test results with hyperemesis gravidarum in Huzhou.Methods 100 cases pregnant women with hyperemesis gravidarum(observa-tion group)and 100 cases non-hyperemesis gravidarum(control group)from Huzhou Maternal and Child Health Hospital from July 2019 to June 2020 were selected,the observation group was divided according to the severity of the disease into the severe group and the mild group,the serum H.pylori antibody,anti-Hp cytotoxin related gene A(CagA)and I3C-urea breath test were tested after entering the group,and the test results,body weight before and during pregnancy,Maternal complications and adverse pregnancy outcomes in perinatal in-fants.Results The positive rates of Hp,CagA and 13C-urea breath in the observation group were higher than those in the control group,and the diference was statistically significant(x2=26.299,44.907,28.926,all P<0.05).The pregnant women in the observation group were grouped according to the severity of the disease.The positive rates of Hp and 13C-urea breath in the severe group were higher than those in the mild group,and the difference was statistically significant(X^(2)=4.005,5.654,all P<0.05).There was no significant differ-ence in CagA positive rate between groups(X^(2)=3.287,P>0.05).The body weight of the observation group in the first trimester was light-er than before pregnancy,and the control group was heavier than before pregnancy.The differences were statistically significant(t=0.279,P<0.05).The body weight of the observation group in the first trimester was lighter than that of the control group,and the difference was statistically significant(t=3.357,P<0.05).There was no statistically significant difference in the incidence of complications between the two groups of pregnant women(P<0.05).The incidence of gestational age and low birth weight in the observation group and the total inci-dence of adverse pregnancy outcomes were higher than those i

关 键 词：妊娠剧吐 13C-尿素呼气实验 抗Hp细胞毒素相关基因A 胃幽门螺杆菌抗体 

分 类 号：R714[医药卫生—妇产科学]