Dawn of a New Era for Membrane Protein Design  

作　　者：Shahin Sowlati-Hashjin Aanshi Gandhi Michael Garton 

机构地区：[1]Institute of Biomedical Engineering,University of Toronto,164 College Street,Toronto,ON,Canada M5S 3E2

出　　处：《BioDesign Research》2022年第1期337-353,共17页生物设计研究（英文）

基　　金：The authors wish to acknowledge the Canadian Institute for Health Research(CIHR)funding that supported this work.

摘　　要：A major advancement has recently occurred in the ability to predict protein secondary structure from sequence using artificialneural networks. This new accessibility to high-quality predicted structures provides a big opportunity for the protein designcommunity. It is particularly welcome for membrane protein design, where the scarcity of solved structures has been a majorlimitation of the field for decades. Here, we review the work done to date on the membrane protein design and set outestablished and emerging tools that can be used to most effectively exploit this new access to structures.

关 键 词：artificial NEURAL EXPLOIT 

分 类 号：Q51[生物学—生物化学]