Collagen-based materials in reproductive medicine and engineered reproductive tissues  

作　　者：Hanxiao Chen Luqi Xue Guidong Gong Jiezhou Pan Xiaoling Wang Yaoyao Zhang Junling Guo Lang Qin 

机构地区：[1]Department of Obstetrics and Gynecology,The Reproductive Medical Center,West China Second University Hospital,Sichuan University,Chengdu 610041,China [2]Key Laboratory of Birth Defects and Related of Women and Children of Ministry of Education,West China Second University Hospital,Sichuan University,Chengdu 610041,China [3]West China School of Medicine,Sichuan University,Chengdu 610041,China [4]BMI Center for Biomass Materials and Nanointerfaces,College of Biomass Science and Engineering,Sichuan University,Chengdu 610065,Sichuan,China [5]State Key Laboratory of Polymer Materials Engineering,Sichuan University,Chengdu 610065,Sichuan,China.

出　　处：《Journal of Leather Science and Engineering》2022年第1期37-51,共15页皮革科学与工程（英文）

基　　金：the Sichuan Science and Technology Program(L.Q.,Grant No.2020YFS0127);the Y.Z.laboratory was financially supported by the Research project of Science&Technology Department of Sichuan Province(Y.Z.,Grant No.2021YJ0416);project of Chengdu Science and Technology Bureau,(Y.Z.,Grant No.2021-YF05-02110-SN)National Natural Science Foundation of China(Y.Z.,Grant No.82001496);China Postdoctoral Science Foundation(Y.Z.,Grant No.2020M680149,2020T130087ZX);the National Global Talents Recruitment Program(J.G.),National Natural Science Foundation of China(22178233);Talents Program of Sichuan Province,Double First Class University Plan of Sichuan University,State Key Laboratory of Polymer Materials Engineering(J.G.,Grant No.sklpme 2020-3-01).

摘　　要：Collagen,the main component of mammal skin,has been traditionally used in leather manufacturing for thousands of years due to its diverse physicochemical properties.Collagen is the most abundant protein in mammals and the main component of the extracellular matrix(ECM).The properties of collagen also make it an ideal building block for the engineering of materials for a range of biomedical applications.Reproductive medicine,especially human fertility preservation strategies and reproductive organ regeneration,has attracted significant attention in recent years as it is key in resolving the growing social concern over aging populations worldwide.Collagen-based biomaterials such as collagen hydrogels,decellularized ECM(dECM),and bioengineering techniques including collagen-based 3D bio-printing have facilitated the engineering of reproductive tissues.This review summarizes the recent progress in apply-ing collagen-based biomaterials in reproductive.Furthermore,we discuss the prospects of collagen-based materials for engineering artificial reproductive tissues,hormone replacement therapy,and reproductive organ reconstruction,aiming to inspire new thoughts and advancements in engineered reproductive tissues research.

关 键 词：Collagen-based biomaterials Leather and collagen Leather tanning process Reproductive medicine Reproductive tissues 

分 类 号：R318.08[医药卫生—生物医学工程]