The role of extracellular matrix on unfavorable maternal-fetal interface:focusing on the function of collagen in human fertility  

作　　者：Rang Liu Mengyuan Dai Guidong Gong Mei Chen Canhui Cao Tianren Wang Zhenhui Hou Yu Shi Junling Guo Yaoyao Zhang Xi Xia 

机构地区：[1]Center for Reproductive Medicine,Peking University Shenzhen Hospital,Futian District,Shenzhen 518000,Guangdong,China [2]Shantou University Medical College,Shantou 515063,Guangdong,China [3]BMI Center for Biomass Materials and Nanointerfaces,College of Biomass Science and Engineering,Chengdu 610065,Sichuan,China [4]Key Laboratory of Birth Defects and Related of Women and Children of Ministry of Education,West China Second University Hospital,Sichuan University,Chengdu 610041,China [5]The University of Hong Kong-Shenzhen Hospital,Center for Reproductive Medicine,Futian District,Shenzhen 518000,Guangdong,China [6]Department of Ultrasonography,Peking University Shenzhen Hospital,Futian District,Shenzhen 518000,Guangdong,China [7]State Key Laboratory of Polymer Materials Engineering,Sichuan University,Chengdu 610065,Sichuan,China [8]The Reproductive Medical Center,Department of Obstetrics and Gynecology,West China Second University Hospital,Sichuan University,Chengdu 610041,China.

出　　处：《Journal of Leather Science and Engineering》2022年第1期184-200,共17页皮革科学与工程（英文）

基　　金：the Research project of Science&Technology Department of Sichuan Province(Y.Z.,Grant No.2021YJ0416);project of Chengdu Science and Technology Bureau,(Y.Z.,Grant No.2021-YF05-02110-SN);National Natural Science Foundation of China(Y.Z.,Grant No.82001496);China Postdoctoral Science Foundation(Y.Z.,Grant No.2020M680149,2020T130087ZX);China Postdoctoral Science Foundation(C.C.,Grant No.2021M702223);Shenzhen Science and Technology Innovation Committee(C.C.,Grant No.JCYJ20210324105808022);the Research Team of Female Reproductive Health and Fertility Preservation(W.Q.,Grant No.SZSM201612065).

摘　　要：Extracellular matrix(ECM)is characterized as widespread,abundant,and pluripotent.Among ECM members,collagen is widely accepted as one of the most prominent components for its essential structural property that can provide a scaffold for other components of ECM and the rich biological functions,which has been extensively used in tissue engineering.Emerging evidence has shown that the balance of ECM degradation and remodeling is vital to regulations of maternal-fetal interface including menstrual cycling,decidualization,embryo implantation and pregnancy maintenance.Moreover,disorders in these events may eventually lead to failure of pregnancy.Although the improvement of assisted conception and embryo culture technologies bring hope to many infertile couples,some unfavorable outcomes,such as recurrent implantation failure(RIF),recurrent pregnancy loss(RPL)or recurrent miscarriage(RM),keep troubling the clinicians and patients.Recently,in vitro three-dimensional(3D)model mimicking the microenvironment of the maternal-fetal interface is developed to investigate the physiological and pathological conditions of conception and pregnancy.The progress of this technology is based on clarifying the role of ECM in the endometrium and the interaction between endometrium and conceptus.Focusing on collagen,the present review summarized the degradation and regulation of ECM and its role in normal menstruation,endometrium receptivity and unsatisfying events occurring in infertility treatments,as well as the application in therapeutic approaches to improve pregnancy outcomes.More investigations about ECM focusing on the maternal-fetal interface interaction with mesenchymal stem cells or local immunoregulation may inspire new thoughts and advancements in the clinical application of infertility treatments.

关 键 词：Collagen Extracellular matrix(ECM) Matrix metalloproteinases(MMPs) ENDOMETRIUM Maternal-fetal interface INFERTILITY 

分 类 号：R339.2[医药卫生—人体生理学]