Wrapping collagen-based nanoparticle with macrophage membrane for treating multidrug-resistant bacterial infection  

作　　者：Yuanyuan Li Jianming Xiong Yi Hu Wenjun Miao He Huang 

机构地区：[1]School of Pharmaceutical Sciences,Nanjing Tech University,Nanjing 211816,People’s Republic of China [2]State Key Laboratory of Materials-Oriented Chemical Engineering,Nanjing Tech University,Nanjing 211816,People’s Republic of China [3]School of Food Science and Pharmaceutical Engineering,Nanjing Normal University,Nanjing 210023,People’s Republic of China.

出　　处：《Journal of Leather Science and Engineering》2022年第1期428-439,共12页皮革科学与工程（英文）

基　　金：the National Natural Science Foundation of China(No.51603101).

摘　　要：Nowadays,multidrug-resistant(MDR)bacterial infectious diseases has become a thorny issue in the healthcare field.Owning to its intrinsic merits,photodynamic therapy(PDT)shows tremendous strengths in fighting against MDR bacterial infections.However,most photodynamic nanoplatforms exhibit unsatisfactory targeting efficiency towards bacteria and infection site,which may compromise the bactericidal effect of PDT.Herein,we firstly reported a bacteria-targeted collagen-based nanoparticle,named Ce6/Col/MM,for treating methicillin-resistant Staphylococ-cus aureus(MRSA)-infected wound.Ce6/Col/MM was fabricated by wrapping chlorin e6(Ce6)-loaded collagen-based nanoparticles with macrophage membrane(MM),showing excellent photodynamic activity and good biocompat-ibility.In vitro studies demonstrated that Ce6/Col/MM could target to bacteria and then exhibit prominent antibacterial capacity against planktonic MRSA under light irradiation.Furthermore,the treatment of MRSA-infected wound in mice with Ce6/Col/MM plus light illumination resulted in potent bacterial inactivation and accelerated wound healing,accompanied by favorable histological compatibility.Collectively,Ce6/Col/MM with superior targeting ability towards bacteria,effective photodynamic antibacterial potency and minimal safety concerns,might be a powerful bactericidal nanoagent for treating infections caused by MDR bacteria。

关 键 词：Collagen Multidrug-resistant bacterial infections Macrophage membrane Photodynamic bactericidal therapy Wound healing 

分 类 号：R446.5[医药卫生—诊断学] TB383.1[医药卫生—临床医学]