补肾法治疗HBeAg阳性慢性HBV感染者临床及相关机制研究  

Research advances in kidney-tonifying therapy for patients with HBeAg-positive chronic HBV infection

作　　者：邢宇锋[1] 韩志毅[1] 周大桥[1] 童光东[1] XING Yufeng;HAN Zhiyi;ZHOU Daqiao;TONG Guangdong(Department of Hepatology,Shenzhen Hospital of Traditional Chinese Medicine,Shenzhen,Guangdong 518033,China)

机构地区：[1]深圳市中医院肝病科,广东深圳518033

出　　处：《临床肝胆病杂志》2023年第6期1267-1273,共7页Journal of Clinical Hepatology

基　　金：国家“十三五”科技重大专项(2018ZX10725505-002);童光东广东省名中医工作室。

摘　　要：慢性HBV感染是HBV自然史中的重要阶段,但对于该阶段的治疗存在一定的争议。中医药自古以来在病毒性肝炎的防治中具有优势,在我国病毒性肝炎的防治中占有重要地位,深圳市中医院团队根据慢性HBV感染的病理过程,认为慢性HBV感染中医核心病机是“肾虚疫毒之邪伏于肝血”,并创立了补肾法治疗慢性HBV感染者;在国家“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项“十一五”“十二五”“十三五”项目支持下,开展了慢性HBV感染者的证候规律研究和系列临床研究,通过多中心、随机、双盲、安慰对照研究了补肾法的临床疗效,为中医药治疗慢性HBV感染者进行了初步探索,探讨了其疗效机制,但慢性HBV感染者的发病机制及其治疗仍然存在较大的难点,随着中医药的传承创新与现代化,相信中医药能够为解决慢性HBV感染者的治疗提供可靠方案。Chronic HBV infection is an important phase in the natural history of HBV,but there are still controversies over the treatment of this stage.Traditional Chinese medicine has had unique advantages in the prevention and treatment of viral hepatitis since ancient times and plays an important role in prevention and treatment of viral hepatitis in China.Based on the pathological process of chronic HBV infection,the team of Department of Hepatology in Shenzhen Hospital of Traditional Chinese Medicine believes that the core pathogenesis of chronic HBV infection is“kidney deficiency and epidemic toxin lurking in liver blood”and established kidney-tonifying therapy for the treatment of chronic HBV infection.Under the support of the project of Prevention and Treatment of Major Infectious Diseases such as AIDS and Viral Hepatitis in The Eleventh Five Year Plan,The Twelfth Five Year Plan,and The Thirteenth Five Year Plan,the team has conducted studies on the regularity of syndromes and a series of clinical studies and investigated the clinical efficacy of kidney-tonifying therapy through multicenter,randomized,double-blind,placebo-controlled studies,thereby exploring the application and mechanism of traditional Chinese medicine treatment in patients with chronic HBV infection.However,there are still difficulties in the pathogenesis and treatment of chronic HBV infection,and with the inheritance,innovation,and modernization of traditional Chinese medicine,it is believed that traditional Chinese medicine can provide reliable regimens for the treatment of chronic HBV infection.

关 键 词：补肾 乙型肝炎病毒 治疗学 

分 类 号：R259[医药卫生—中西医结合]