抑制性受体TIGIT与慢性HBV感染中免疫紊乱的关系  

Association of inhibitory receptor T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain with immune disorders in chronic HBV infection

作　　者：周玉霞 王彩红 姚晓文 王蓉[1] 郑晓凤[3] 于晓辉 张久聪 ZHOU Yuxia;WANG Caihong;YAO Xiaowen;WANG Rong;ZHENG Xiaofeng;YU Xiaohui;ZHANG Jiucong(The First Clinical Medical College of Gansu University of Chinese Medicine,Lanzhou 730030,China;Department of Gastroenterology,The 940 Hospital of Joint Logistic Support Force of PLA,Lanzhou 730050,China;Department of Gastroenterology,The Second Hospital of Lanzhou University,Lanzhou 730030,China)

机构地区：[1]甘肃中医药大学第一临床医学院,兰州730030 [2]中国人民解放军联勤保障部队第九四〇医院消化内科,兰州730050 [3]兰州大学第二医院消化内科,兰州730030

出　　处：《临床肝胆病杂志》2023年第6期1418-1423,共6页Journal of Clinical Hepatology

基　　金：国家自然科学基金(81500454);第九四〇医院拔尖项目(2021yxky002)。

摘　　要：持续HBV感染改变了天然免疫细胞和获得性免疫细胞表面受体的表达,由此引发的多种免疫紊乱,可导致免疫逃逸,最终使疾病慢性化。研究表明,抑制性受体的上调是患者免疫紊乱的主要原因,阻断抑制性受体可一定程度上恢复患者的免疫功能。T淋巴细胞免疫球蛋白和免疫受体酪氨酸抑制性基序结构域(TIGIT)是目前较为关注的一种新型抑制性受体,在NK细胞和T淋巴细胞中高水平表达。研究发现,TIGIT在慢性病毒感染中发挥重要作用,现就TIGIT与慢性HBV感染中免疫紊乱的相关性研究进展进行简要综述。Persistent HBV infection alters the expression of receptors on the surface of innate and acquired immune cells,which may cause a variety of immune disorders and finally lead to immune escape and disease chronicity.Studies have shown that the upregulation of inhibitory receptors is the main cause of immune disorders in patients,and blocking inhibitory receptors can restore immune function to a certain extent.T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain(TIGIT)is a new type of inhibitory receptor attracting much attention at present,and it is highly expressed in NK cells and T cells.It has been found that TIGIT plays an important role in chronic viral infection,and this article briefly reviews the research advances in the association between TIGIT and immune disorders in chronic HBV infection.

关 键 词：乙型肝炎病毒 受体 免疫 免疫紊乱 

分 类 号：R512.62[医药卫生—内科学]