中医药干预TLR4/NLRP3信号通路治疗抑郁症的研究概况  

Overview of Research in Traditional Chinese Medicine for the Treatment of Depression by Intervention on TLR4/NLRP3 Signaling Pathway

作　　者：张勇[1] 刘美君[2] 李锐锋 蔡君洁 何媛 常文 邓鑫敏 梁静涛[2] ZHANG Yong;LIU Meijun;LI Ruifeng;CAI Junjie;HE Yuan;CHANG Wen;DENG Xinmin;LIANG Jingtao(Chengdu University of Traditional Chinese Medicine,Chengdu,610075;Hospital of Chengdu University of Traditional Chinese Medicine)

机构地区：[1]成都中医药大学,四川省成都市610075 [2]成都中医药大学附属医院

出　　处：《中医杂志》2023年第11期1179-1184,共6页Journal of Traditional Chinese Medicine

基　　金：四川省科学技术厅重点研发项目(2021YFS0260)。

摘　　要：应激诱导的免疫/炎症反应是抑郁症发生发展的关键病理机制,模式识别受体Toll样受体4(TLR4)/NOD样受体蛋白3(NLRP3)信号通路介导的免疫/炎症反应与抑郁症的形成和发展密切相关。中医药有关该通路抗抑郁的机制研究近年来成为关注点之一,中药复方如逍遥散、柴胡疏肝散、小建中汤等,中药药对如柴胡-白芍、桂枝-白芍、栀子-川芎等,中药单体如红花提取物、去氧五味子素、银杏酮酯、麝香酮、女贞子酚苷等可能通过抑制TLR4/NLRP3信号通路,下调TLR4、NLRP3、髓样分化因子88(MyD88)、核转录因子κB(NF-κB)、信号转接凋亡相关斑点样蛋白(ASC)等关键蛋白表达及白细胞介素1β(IL-1β)、白细胞介素18(IL-18)、肿瘤坏死因子α(TNF-α)等炎症因子水平,调控应激诱导的免疫/炎症反应,发挥抗抑郁作用。建议今后采用多种现代检测技术,从不同维度、不同层次,进一步探索中医药在TLR4/NLRP3信号通路中的抗抑郁机制,为中医药治疗抑郁症提供更多科学有力的证据。The immune/inflammatory response induced by stress is a key pathological mechanism for the occurrence and development of depression.The immune/inflammatory response mediated by the Toll-like receptor 4(TLR4)/NOD like receptor protein 3(NLRP3)signaling pathway is closely related to the formation and development of depression.In recent years,researches on the antidepressant mechanism of the TLR4/NLRPS pathway in traditional Chinese medicine(TCM)has become a hot topic.TCM compound formulas such as Xiaoyao Powder(逍遥散),Chaihu Shugan Powder(柴胡疏肝散),and Xiaojianzhong Decoction(小建中汤),herbal pairs such as Chaihu(Radix Bupleuri)-Baishao(Radix Paeoniae Alba),Guizhi(Ramulus Cinnamomi)-Baishao(Radix Paeoniae Alba),and Zhizi(Fructus Gardeniae)-Chuanxiong(Rhizoma Chuanxiong),and monomers such as extract of Honghua(Flos Carthami),deoxyschizandrin,ginkgo ketone ester,muscone,and citrus glycosides,may be possible to inhibit the TLR4/NLRP3 signaling pathway and down-regulate the expression of key proteins such as TLR4,NLRP3,myeloid differentiation factor 88(MyD88),nuclear transcription factorκB(NF-κB),and signal transduction apoptosis-associated speck-like protein(ASC),as well as the levels of inflammatory factors such as interleukin 1β(IL-1β),interleukin 18(IL-18),and tumor necrosis factorα(TNF-α),thereby regulating stress-induced immune/inflammatory responses and exert antidepressant effects.It is suggested that various modern detection techniques be used in the future to further explore the antidepressant mechanism of TLR4/NLRP3 signaling pathway from different dimensions and levels,so as to provide more scientific and powerful evidence for the treatment of depression with TCM.

关 键 词：抑郁症 TLR4/NLRP3信号通路 中药 免疫/炎症反应 应激 

分 类 号：R277.7[医药卫生—中医学]