睡眠相关标记物在预测围手术期睡眠障碍中的研究进展  

Research progress of sleep‑related markers in predicting perioperative sleep disorder

作　　者：高一 李运 张析哲[3] 宋健楠[3] 梁晓东[3] 于淼[3] 周琪[3] Gao Yi;Li Yun;Zhang Xizhe;Song Jiannan;Liang Xiaodong;Yu Miao;Zhou Qi(Chifeng Clinical Medical College of Inner Mongolia Medical University,Chifeng 024000,China;Department of Anesthesiology,Tianjin Medical University General Hospital,Tianjin Research Institute of Anesthesiology,Tianjin 300052,China;Department ofAnesthesiology,Chifeng Municipal Hospital,Chifeng 024000,China)

机构地区：[1]内蒙古医科大学赤峰临床医学院,赤峰024000 [2]天津医科大学总医院麻醉科,天津市麻醉学研究所,天津300052 [3]赤峰市医院麻醉科,赤峰024000

出　　处：《国际麻醉学与复苏杂志》2023年第4期438-442,共5页International Journal of Anesthesiology and Resuscitation

基　　金：内蒙古自治区卫生健康科技计划项目(202202327);赤峰市自然科学基金(SZR2022217);天津市教委科研计划项目(2022KJ232)。

摘　　要：目前已有证据表明,一些潜在的睡眠相关标记物与围手术期睡眠障碍的发生存在密切联系,可能对围手术期睡眠障碍的预测及诊断提供有价值的参考。文章综述睡眠相关标记物,如食欲素(orexin)系统、Homer1a蛋白、代谢型谷氨酸受体5(metabotropic glutamate receptor 5,mGluR5)调节蛋白、黑色素聚集激素(melanin⁃concentrating hormone,MCH)系统、β淀粉样蛋白(amyloidβ⁃protein,Aβ)、Tau蛋白、突触结合蛋白(synaptotagmin,SYT)等,在预测围手术期睡眠障碍中的潜在价值,旨在为完善围手术期睡眠障碍的预测及诊断提供新的侧重点。Some evidence indicates that some potential sleep⁃related markers are closely related to perioperative sleep disorder,which may provide a valuable reference for its prediction and diagnosis.This review summarizes the potential value of these sleep⁃related markers in the prediction of perioperative sleep disorder,such as orexin system,Homer1a protein,metabotropic glutamate receptor 5(mGluR5)regulatory protein,melanin⁃concentrating hormone(MCH)system,amyloidβ⁃protein(Aβ),Tau protein,synapto⁃tagmin(SYT),and aims to provide new ideas for perfecting the prediction and diagnosis of perioperative sleep disorder.

关 键 词：围手术期 睡眠障碍 标志物 

分 类 号：R614[医药卫生—麻醉学]