Effectiveness of Fuling(Poria) and its extracts against spleen deficiency in rats via tonifying spleen  

作　　者：FENG Min JIA Ziming WAN Ming FAN Bolin TANG Xiaoqiao CHENG Wenhua SUN Fanzhong 

机构地区：[1]Hubei Provincial Key Laboratory of Applied Toxicology,Hubei Provincial Center for Disease Control and Prevention,Wuhan 430075,China [2]Department of pharmaceutical affairs,Hubei Provincial Hospital of TCM,Wuhan 430074,China

出　　处：《Journal of Traditional Chinese Medicine》2023年第3期501-506,共6页中医杂志（英文版）

基　　金：Supported by National Key Research and Development Program of China:Study on the Core Efficacy Evaluation of Fuling(Poria)(No.2017YFC1703005)。

摘　　要：OBJECTIVE:To observe and explore the effect of Fuling(Poria) in alleviating the spleen deficiency symptom pattern(SDSP).METHODS:We established an animal model of SDS in Sprague-Dawley(SD) rats by treating them with deficiency-inducing factors,including irregular feeding and tail clamping.Mice were administered Fuling(Poria) and its extracts(raw/cooked powder,aqueous/alcohol extract) by gavage once a day for 21 d.The body weight,rectal temperature,and spleen and thymus organ coefficients were calculated.The levels of motilin(MTL),gastrin(GAS),aquaporin 2(AQP2),interleukin 2(IL-2),IL-4,and 5-hydroxytryptamine(5-HT) in the serum and the level of AQP2 in the kidneys were evaluated by enzyme-linked immunosorbent assay.RESULTS:Fuling(Poria) and its extracts did not change the body weight,rectal temperature,and organ coefficients of the spleen and thymus.However,it reduced the levels of MTL and GAS and increased the levels of IL-2 and AQP2.In addition,the levels of IL-4 and 5-HT showed no significant alteration.CONCLUSIONS:These results suggested the crucial function of Fuling(Poria) in SDSP,especially promoting digestive function and water metabolism.

关 键 词：Fuling(Poria) EXTRACTS spleen deficiency symptom pattern MOTILIN GASTRINS INTERLEUKINS aquaporin 2 SEROTONIN 

分 类 号：R285.5[医药卫生—中药学]