外用消胀贴治疗气滞型功能性消化不良餐后不适综合征的临床研究  

Clinical observation of Xiaozhang Paster in the treatment of postprandial discomfort syndrome of qi stagnation functional dyspepsia

作　　者：张海燕[1] 宗湘裕[1] 高晓珊 高翔 王宝绪 Haiyan Zhang;Xiangyu Zong;Xiaoshan Gao;Xiang Gao;Baoxu Wang(Department of Gastroenterology,Beijing Huairou District Hospital of Traditional Chinese Medicine,Beijing 101400,China)

机构地区：[1]北京市怀柔区中医医院消化科,北京101400

出　　处：《国际中医中药杂志》2023年第6期694-698,共5页International Journal of Traditional Chinese Medicine

基　　金：北京市怀柔区中医医院课题(2020-MP09)。

摘　　要：目的评价外用消胀贴治疗气滞型功能性消化不良(FD)餐后不适综合征的疗效。方法随机对照试验设计。选取2019年1月-2022年1月本院128例气滞型FD餐后不适综合征患者作为观察对象,采用随机数字表法分为2组,每组64例。2组均口服枸橼酸莫沙比利片,在此基础上治疗组给予外用消胀贴,对照组给予安慰剂贴。2组均治疗2周。分别于治疗前后进行中医证候评分及症状严重程度与发作频率评分,采用SF-36健康状况调查简表(SF-36)评估生活质量,医院焦虑抑郁量表(HADS)评估焦虑、抑郁程度;采用ELISA法检测生长激素释放肽(Ghrelin)、降钙素基因相关肽(CGRP)、胃泌素17(G-17)、胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)水平;评价临床疗效。结果治疗组总有效率为96.88%(62/64)、对照组为81.25%(52/64),2组比较差异有统计学意义(χ^(2) =8.02,P<0.05)。治疗后,治疗组胃脘痞闷、胃脘胀痛、两胁胀满、纳呆积分及总分低于对照组(t值分别为38.43、32.39、38.43、32.87、33.74,P<0.01),症状严重程度与发作频率评分低于对照组(t值分别为61.42、33.46,P<0.01),SF-36评分高于对照组(t=8.26,P<0.01),HADS评分低于对照组(t=38.06,P<0.01);治疗后,治疗组CGRP、G-17水平低于对照组(t值分别为6.22、29.51,P<0.01),Ghrelin水平及PGⅠ、PGⅡ水平高于对照组(t值分别为23.85、13.26、19.53,P<0.01)。结论在口服枸橼酸莫沙比利片基础上结合外用消胀贴可提高气滞型FD餐后不适综合征患者的生活质量,改善患者胃肠激素水平及焦虑、抑郁状态。Objective To explore the clinical observation of Xiaozhang Plaster for external use in the treatment of postprandial discomfort syndrome of qi stagnation functional dyspepsia.Methods Randomized controlled trial.From January 2019 to January 2022,128 patients with postprandial discomfort syndrome of functional dyspepsia of qi stagnation type in our hospital were selected and divided into two groups by random number table,with 64 cases in each group.Both groups were orally treated with mosapride citrate tablets.On this basis,the treatment group was combined with external use of Xiaozhang Plaster,and the control group was combined with placebo patch.Both groups were treated for 2 weeks.Traditional Chinese Medicine syndrome score,symptom severity and attack frequency score were performed before and after treatment.The quality of life of the patients was assessed with SF-36 Short-form health survey-36(SF-36),anxiety and depression were assessed with Hospital Anxiety and Depression Scale(HADS),and the growth hormone releasing peptide(Ghrelin),calcitonin gene-related peptide(CGRP)The levels of gastrin 17(G-17),pepsinogen I(PG I)and pepsinogenⅡ(PGⅡ)levels were observed by ELISA,and clinical efficacy was evaluated.Results The total effective rate was 96.88%(62/64)in the treatment group and 81.25%(52/64)in the control group.The difference between the two groups was statistically significant(χ^(2) =8.02,P<0.05).After treatment,the score and total score of epigastric distension,epigastric distension and pain,fullness of both flanks,loss of appetite in the treatment group were significantly lower than those in the control group(t=38.43,32.39,38.43,32.87,33.74,P<0.01),the score of symptom severity and attack frequency were significantly lower than those in the control group(t=61.42,33.46,P<0.01),and the score of SF-36 was significantly higher than that in the control group(t=8.26,P<0.01);The score of HADS was significantly lower than that of the control group(t=38.06,P<0.01).After treatment,the levels of CGRP and G-17 in t

关 键 词：消化不良 穴位贴敷疗法 消胀贴 中医症状体征和证候 

分 类 号：R259[医药卫生—中西医结合]